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    Nup42 nucleoporin 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup42provided by RGD
    Official Full Name
    nucleoporin 42provided by RGD
    Primary source
    RGD:1560934
    See related
    EnsemblRapid:ENSRNOG00000010435 AllianceGenome:RGD:1560934
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nupl2; RGD1560934
    Summary
    Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to be located in cytosol; nucleoplasm; and photoreceptor outer segment. Predicted to be part of nuclear pore. Predicted to colocalize with nuclear envelope. Orthologous to human NUP42 (nucleoporin 42). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 40.2), Thymus (RPKM 38.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nup42 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11877957..11894991, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10985554..11002591, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7512326..7529106, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily H member 2 Neighboring gene uncharacterized LOC108350647 Neighboring gene uncharacterized LOC134486544 Neighboring gene kelch-like family member 7 Neighboring gene uncharacterized LOC134486543 Neighboring gene hyccin PI4KA lipid kinase complex subunit 1 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent nuclear protein export. Waldmann I, et al. J Cell Sci, 2012 Jan 1. PMID 22250199
    2. A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. Farjot G, et al. J Biol Chem, 1999 Jun 11. PMID 10358091
    3. Tulp1 is involved in specific photoreceptor protein transport pathways. Hagstrom SA, et al. Adv Exp Med Biol, 2012. PMID 22183407
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin NUP42
    Names
    nucleoporin like 2
    nucleoporin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109217.1 → NP_001102687.1  nucleoporin NUP42

      See identical proteins and their annotated locations for NP_001102687.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474020
      UniProtKB/TrEMBL
      A0A8I5ZS72, A6K571, D3ZHV0
      Related
      ENSRNOP00000013865.3, ENSRNOT00000013865.5
      Conserved Domains (1) summary
      smart00356
      Location:1 → 23
      ZnF_C3H1; zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11877957..11894991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108071.2 → XP_038963999.1  nucleoporin NUP42 isoform X1

      Conserved Domains (1) summary
      PRK14959
      Location:119 → 224
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional

    2. XM_039108069.2 → XP_038963997.1  nucleoporin NUP42 isoform X1

      Conserved Domains (1) summary
      PRK14959
      Location:119 → 224
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional

    3. XM_039108070.2 → XP_038963998.1  nucleoporin NUP42 isoform X1

      Conserved Domains (1) summary
      PRK14959
      Location:119 → 224
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional

    4. XM_039108072.2 → XP_038964000.1  nucleoporin NUP42 isoform X2

      UniProtKB/TrEMBL
      A6K572
      Conserved Domains (1) summary
      PRK14959
      Location:56 → 161
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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