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    Eri2 ERI1 exoribonuclease family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eri2provided by RGD
    Official Full Name
    ERI1 exoribonuclease family member 2provided by RGD
    Primary source
    RGD:1583889
    See related
    EnsemblRapid:ENSRNOG00000014673 AllianceGenome:RGD:1583889
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Exod1
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Orthologous to human ERI2 (ERI1 exoribonuclease family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 196.4), Liver (RPKM 107.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eri2 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183551919..183600134, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (174140831..174168757, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189540145..189549891, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene uncharacterized LOC134483776 Neighboring gene acyl-CoA synthetase medium-chain family member 4 Neighboring gene THUMP domain containing 1 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene RNA exonuclease 5 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene LYR motif containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene dynein, axonemal, heavy chain 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ERI1 exoribonuclease 2
    Names
    exonuclease domain containing 1
    exonuclease domain containing 1-like
    exoribonuclease 2
    NP_001178043.1
    XP_038947521.1
    XP_038947532.1
    XP_038947536.1
    XP_063130950.1
    XP_063130951.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191114.1 → NP_001178043.1  ERI1 exoribonuclease 2

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4A625
      Related
      ENSRNOP00000019747.5, ENSRNOT00000019747.8
      Conserved Domains (2) summary
      cd06133
      Location:37 → 230
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
      pfam06839
      Location:592 → 640
      zf-GRF; GRF zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183551919..183600134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091593.2 → XP_038947521.1  ERI1 exoribonuclease 2 isoform X1

      Conserved Domains (2) summary
      cd06133
      Location:37 → 254
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
      pfam06839
      Location:616 → 663
      zf-GRF; GRF zinc finger

    2. XM_063274880.1 → XP_063130950.1  ERI1 exoribonuclease 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9P0

    3. XM_063274881.1 → XP_063130951.1  ERI1 exoribonuclease 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A9P0

    4. XM_039091604.2 → XP_038947532.1  ERI1 exoribonuclease 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9P0
      Conserved Domains (1) summary
      cd06133
      Location:37 → 254
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    5. XM_039091608.2 → XP_038947536.1  ERI1 exoribonuclease 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A9P0
      Related
      ENSRNOP00000089192.1, ENSRNOT00000106664.2
      Conserved Domains (1) summary
      cd06133
      Location:37 → 254
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RNA

    1. XR_010058148.1 RNA Sequence

    2. XR_010058149.1 RNA Sequence

    3. XR_005492892.2 RNA Sequence

    4. XR_005492893.2 RNA Sequence

    5. XR_010058185.1 RNA Sequence

    6. XR_005492882.2 RNA Sequence

    7. XR_010058147.1 RNA Sequence

    8. XR_010058143.1 RNA Sequence

    9. XR_010058180.1 RNA Sequence

    10. XR_010058182.1 RNA Sequence

    11. XR_005492899.2 RNA Sequence

    12. XR_010058153.1 RNA Sequence

    13. XR_010058151.1 RNA Sequence

    14. XR_010058155.1 RNA Sequence

    15. XR_010058150.1 RNA Sequence

    16. XR_010058163.1 RNA Sequence

    17. XR_010058191.1 RNA Sequence

    18. XR_005492896.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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