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    Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform [ Mus musculus (house mouse) ]

    Gene ID: 14208, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppm1gprovided by MGI
    Official Full Name
    protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoformprovided by MGI
    Primary source
    MGI:MGI:106065
    See related
    Ensembl:ENSMUSG00000029147 AllianceGenome:MGI:106065
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fin13
    Summary
    Enables phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study schizophrenia. Orthologous to human PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 177.4), liver E14 (RPKM 82.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppm1g in Genome Data Viewer
    Location:
    5 B1; 5 17.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31360012..31377889, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31202668..31220545, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513 Neighboring gene STARR-seq mESC enhancer starr_12768 Neighboring gene predicted gene 9970 Neighboring gene nuclear receptor binding protein 1 Neighboring gene keratinocyte associated protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein phosphatase 1G
    Names
    PP2C-gamma
    fibroblast growth factor inducible 13
    fibroblast growth factor-inducible protein 13
    protein phosphatase 1C
    protein phosphatase magnesium-dependent 1 gamma
    NP_032040.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008014.3NP_032040.1  protein phosphatase 1G

      See identical proteins and their annotated locations for NP_032040.1

      Status: PROVISIONAL

      Source sequence(s)
      AC114619
      Consensus CDS
      CCDS19179.1
      UniProtKB/Swiss-Prot
      Q61074
      UniProtKB/TrEMBL
      A0A0J9YVG0
      Related
      ENSMUSP00000031032.8, ENSMUST00000031032.11
      Conserved Domains (2) summary
      smart00332
      Location:25110
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
      cd00143
      Location:321502
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31360012..31377889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)