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    Mesp1 mesoderm posterior 1 [ Mus musculus (house mouse) ]

    Gene ID: 17292, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mesp1provided by MGI
    Official Full Name
    mesoderm posterior 1provided by MGI
    Primary source
    MGI:MGI:107785
    See related
    Ensembl:ENSMUSG00000030544 AllianceGenome:MGI:107785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bHLHc5
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; negative regulation of cell fate specification; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cardioblast migration; mesodermal cell migration; and signal transduction involved in regulation of gene expression. Located in nucleus. Is expressed in several structures, including allantois; central nervous system; embryo mesenchyme; primitive streak; and sensory organ. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human MESP1 (mesoderm posterior bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 56.3) and lung adult (RPKM 11.0) See more
    Orthologs
    NEW
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    Genomic context

    See Mesp1 in Genome Data Viewer
    Location:
    7 D2; 7 45.16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79441989..79443338, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79792241..79793590, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 93 Neighboring gene predicted gene 44705 Neighboring gene mesoderm posterior 2 Neighboring gene alanyl aminopeptidase, membrane

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC159208, MGC159210

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac atrium formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac atrium formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac cell fate determination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac vascular smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac vascular smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac ventricle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac ventricle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardioblast anterior-lateral migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardioblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardioblast migration to the midline involved in heart field formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic heart tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gastrulation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in growth involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lateral mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mesodermal cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endodermal cell fate specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mesodermal cell fate specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of hepatocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of striated muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in secondary heart field specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sinoatrial node cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sinoatrial node cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sinus venosus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somite rostral/caudal axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mesoderm posterior protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008588.2NP_032614.2  mesoderm posterior protein 1

      See identical proteins and their annotated locations for NP_032614.2

      Status: VALIDATED

      Source sequence(s)
      BC125505, CF105615
      Consensus CDS
      CCDS21387.1
      UniProtKB/Swiss-Prot
      P97309, Q059W2
      Related
      ENSMUSP00000032760.6, ENSMUST00000032760.6
      Conserved Domains (1) summary
      pfam00010
      Location:77130
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79441989..79443338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)