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    Zfp692 zinc finger protein 692 [ Mus musculus (house mouse) ]

    Gene ID: 103836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp692provided by MGI
    Official Full Name
    zinc finger protein 692provided by MGI
    Primary source
    MGI:MGI:2144276
    See related
    Ensembl:ENSMUSG00000037243 AllianceGenome:MGI:2144276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf692; Zfp692-ps
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in kinetochore. Is expressed in several structures, including 1st branchial arch; limb; male reproductive system; maxillary process; and urinary system. Orthologous to human ZNF692 (zinc finger protein 692). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 26.7), CNS E18 (RPKM 23.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp692 in Genome Data Viewer
    Location:
    11 B1.3; 11 36.19 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58197883..58205971)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58307057..58315145)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39827 Neighboring gene nuclear encoded tRNA glutamic acid 10 (anticodon CTC) Neighboring gene STARR-positive B cell enhancer ABC_E2989 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAA) Neighboring gene zinc finger protein 672 Neighboring gene STARR-positive B cell enhancer ABC_E3953 Neighboring gene SH3 binding domain protein 5 like Neighboring gene predicted gene, 33660

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo. Shirai T, et al. Biochem Biophys Res Commun, 2011 Oct 22. PMID 21910974
    2. Retinal transcriptome of neonatal mice after optic nerve injury. Yao SQ, et al. PLoS One, 2023. PMID 37252932, Free PMC Article
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AREBP is a key modulator of hepatic glucose production regulated by AMPK in vivo.
      Title: AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 692
    Names
    AICAR responsive element binding protein
    zinc finger protein 692, pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040686.1 → NP_001035776.1  zinc finger protein 692

      See identical proteins and their annotated locations for NP_001035776.1

      Status: VALIDATED

      Source sequence(s)
      AL845463
      Consensus CDS
      CCDS36162.1
      UniProtKB/Swiss-Prot
      Q3U381
      UniProtKB/TrEMBL
      B2RX02
      Related
      ENSMUSP00000126674.2, ENSMUST00000153510.9
      Conserved Domains (4) summary
      COG5048
      Location:383 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:360 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:402 → 427
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:328 → 406
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_182996.3 → NP_892041.2  zinc finger protein 692

      See identical proteins and their annotated locations for NP_892041.2

      Status: VALIDATED

      Source sequence(s)
      AL845463
      Consensus CDS
      CCDS36162.1
      UniProtKB/Swiss-Prot
      Q3U381
      UniProtKB/TrEMBL
      B2RX02
      Related
      ENSMUSP00000131896.2, ENSMUST00000049353.9
      Conserved Domains (4) summary
      COG5048
      Location:383 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:360 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:402 → 427
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:328 → 406
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58197883..58205971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156191.1 → XP_036012084.1  zinc finger protein 692 isoform X1

      Conserved Domains (3) summary
      COG5236
      Location:229 → 344
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:232 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:200 → 278
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_036156192.1 → XP_036012085.1  zinc finger protein 692 isoform X1

      Conserved Domains (3) summary
      COG5236
      Location:229 → 344
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:232 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:200 → 278
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_006531919.4 → XP_006531982.1  zinc finger protein 692 isoform X1

      See identical proteins and their annotated locations for XP_006531982.1

      Conserved Domains (3) summary
      COG5236
      Location:229 → 344
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:232 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:200 → 278
      zf-C2H2_8; C2H2-type zinc ribbon

    4. XM_036156193.1 → XP_036012086.1  zinc finger protein 692 isoform X1

      Conserved Domains (3) summary
      COG5236
      Location:229 → 344
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:232 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:200 → 278
      zf-C2H2_8; C2H2-type zinc ribbon

    5. XM_006531920.2 → XP_006531983.1  zinc finger protein 692 isoform X1

      See identical proteins and their annotated locations for XP_006531983.1

      Conserved Domains (3) summary
      COG5236
      Location:229 → 344
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:232 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:200 → 278
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U381.1 GenPept UniProtKB/Swiss-Prot:Q3U381

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