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    Hint1 histidine triad nucleotide binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 15254, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hint1provided by MGI
    Official Full Name
    histidine triad nucleotide binding protein 1provided by MGI
    Primary source
    MGI:MGI:1321133
    See related
    Ensembl:ENSMUSG00000020267 AllianceGenome:MGI:1321133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hint; Ipk1; PKCI-1; PRKCNH1
    Summary
    Enables deSUMOylase activity. Involved in positive regulation of calcium-mediated signaling and protein desumoylation. Located in nucleus. Is expressed in several structures, including genitourinary system; gut; mammary gland; nervous system; and spleen. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 346.0), duodenum adult (RPKM 283.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hint1 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54757209..54761332)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54866383..54870506)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene LYR motif containing 7 Neighboring gene STARR-seq mESC enhancer starr_29513 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54663563-54663764 Neighboring gene ATPase family, AAA domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29515 Neighboring gene predicted gene, 31490 Neighboring gene VISTA enhancer mm1343 Neighboring gene glutathione peroxidase 3 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E11481 Neighboring gene 40S ribosomal protein S11-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenosine 5'-monophosphoramidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenosine 5'-monophosphoramidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables deSUMOylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deSUMOylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein desumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purine ribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in purine ribonucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine ribonucleotide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone deacetylase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenosine 5'-monophosphoramidase HINT1
    Names
    PKC inhibitor/ interacting protein
    adenosine 5'-monophosphoramidase
    desumoylating isopeptidase HINT1
    protein kinase C inhibitor 1
    protein kinase C-interacting protein 1
    NP_032274.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008248.3NP_032274.1  adenosine 5'-monophosphoramidase HINT1

      See identical proteins and their annotated locations for NP_032274.1

      Status: VALIDATED

      Source sequence(s)
      BC070415, BE995722, BY261801
      Consensus CDS
      CCDS24702.1
      UniProtKB/Swiss-Prot
      P70349
      Related
      ENSMUSP00000020504.6, ENSMUST00000020504.6
      Conserved Domains (1) summary
      cd01276
      Location:16118
      PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54757209..54761332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)