Sf3b3 splicing factor 3b, subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sf3b3provided by MGI
Official Full Name: splicing factor 3b, subunit 3provided by MGI
Primary source: MGI:MGI:1289341
See related: Ensembl:ENSMUSG00000033732 AllianceGenome:MGI:1289341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RSE1; SAP130; SF3b130; mKIAA0017; D8Ertd633e; 1810061H24Rik; 5730409A01Rik
Summary: Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of protein catabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of U2 snRNP and spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human SF3B3 (splicing factor 3b subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 30.3), limb E14.5 (RPKM 23.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 57.73 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (111537123..111573578, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (110810491..110846806, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.
Title: Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sf3b3 (e-PCR), detects polymorphism
- UniSTS:479259

RH124840 (e-PCR)
- UniSTS:161662

AU015046 (e-PCR)
- UniSTS:167587

NoName (e-PCR)
- UniSTS:236002

NoName (e-PCR)
- UniSTS:236005

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables U2 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of RNA splicing	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
part_of U12-type spliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of U12-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of U2-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2-type spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: splicing factor 3B subunit 3

Names: SAP 130; pre-mRNA-splicing factor SF3b 130 kDa subunit; spliceosome-associated protein 130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133953.2 → NP_598714.1 splicing factor 3B subunit 3

See identical proteins and their annotated locations for NP_598714.1

Status: VALIDATED

Source sequence(s)

AK128988, BC042580, BY126146

Consensus CDS

CCDS22665.1

UniProtKB/Swiss-Prot

Q3UGI3, Q6ZQL0, Q8BUD9, Q8K2J8, Q921M3

UniProtKB/TrEMBL

B2RSV4

Related

ENSMUSP00000045073.6, ENSMUST00000042012.7

Conserved Domains (2) summary

pfam03178
Location:863 → 1182

CPSF_A; CPSF A subunit region

pfam10433
Location:76 → 592

MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

111537123..111573578 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530518.5 → XP_006530581.1 splicing factor 3B subunit 3 isoform X1

See identical proteins and their annotated locations for XP_006530581.1

UniProtKB/Swiss-Prot

Q3UGI3, Q6ZQL0, Q8BUD9, Q8K2J8, Q921M3

UniProtKB/TrEMBL

B2RSV4

Conserved Domains (2) summary

pfam03178
Location:863 → 1182

CPSF_A; CPSF A subunit region

pfam10433
Location:76 → 592

MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
XM_030243208.2 → XP_030099068.1 splicing factor 3B subunit 3 isoform X2

Conserved Domains (1) summary

pfam03178
Location:296 → 615

CPSF_A; CPSF A subunit region