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    Foxred2 FAD-dependent oxidoreductase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 239554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Foxred2provided by MGI
    Official Full Name
    FAD-dependent oxidoreductase domain containing 2provided by MGI
    Primary source
    MGI:MGI:106315
    See related
    Ensembl:ENSMUSG00000016552 AllianceGenome:MGI:106315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm304; D15Bwg0759e; A430097D04Rik
    Summary
    Predicted to enable flavin adenine dinucleotide binding activity and monooxygenase activity. Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum lumen. Is expressed in brain; eye; gonad; and submandibular gland. Orthologous to human FOXRED2 (FAD dependent oxidoreductase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 11.3), cerebellum adult (RPKM 5.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Foxred2 in Genome Data Viewer
    Location:
    15 E1; 15 36.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77824722..77842701, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77940522..77958503, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53901 Neighboring gene STARR-seq mESC enhancer starr_39132 Neighboring gene STARR-positive B cell enhancer ABC_E479 Neighboring gene thioredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E3146 Neighboring gene eukaryotic translation initiation factor 3, subunit D Neighboring gene calcium channel, voltage-dependent, gamma subunit 2 Neighboring gene predicted gene, 46520 Neighboring gene STARR-seq mESC enhancer starr_39138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FAD-dependent oxidoreductase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017983.3 → NP_001017983.2  FAD-dependent oxidoreductase domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_001017983.2

      Status: VALIDATED

      Source sequence(s)
      AL583886, AL589650
      Consensus CDS
      CCDS27607.1
      UniProtKB/Swiss-Prot
      Q3TCC4, Q3USW5, Q5RJH0
      Related
      ENSMUSP00000016696.7, ENSMUST00000016696.13
      Conserved Domains (1) summary
      pfam13738
      Location:25 → 240
      Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_001168260.2 → NP_001161732.1  FAD-dependent oxidoreductase domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_001161732.1

      Status: VALIDATED

      Source sequence(s)
      AL583886, AL589650
      Consensus CDS
      CCDS27607.1
      UniProtKB/Swiss-Prot
      Q3TCC4, Q3USW5, Q5RJH0
      Related
      ENSMUSP00000113403.2, ENSMUST00000117725.2
      Conserved Domains (1) summary
      pfam13738
      Location:25 → 240
      Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      77824722..77842701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520943.5 → XP_006521006.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:26 → 311
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_036159400.1 → XP_036015293.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:31 → 373
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_006520945.4 → XP_006521008.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:26 → 311
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_004938836.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3USW5.1 GenPept UniProtKB/Swiss-Prot:Q3USW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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