U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Sgms1 sphingomyelin synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 208449, updated on 10-Dec-2024

    Summary

    Official Symbol
    Sgms1provided by MGI
    Official Full Name
    sphingomyelin synthase 1provided by MGI
    Primary source
    MGI:MGI:2444110
    See related
    Ensembl:ENSMUSG00000040451 AllianceGenome:MGI:2444110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mob; Sms1; Sor1; Tmem23; 9530058O11Rik
    Summary
    Enables ceramide phosphoethanolamine synthase activity and sphingomyelin synthase activity. Involved in sphingomyelin biosynthetic process. Acts upstream of or within ceramide biosynthetic process. Predicted to be located in Golgi trans cisterna. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; limb; and respiratory system. Orthologous to human SGMS1 (sphingomyelin synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 37.1), genital fat pad adult (RPKM 8.2) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sgms1 in Genome Data Viewer
    Location:
    19 C1; 19 26.68 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32100127..32367285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32122727..32389885, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene APOBEC1 complementation factor Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7645 Neighboring gene N-acylsphingosine amidohydrolase 2 Neighboring gene VISTA enhancer mm1654 Neighboring gene coiled-coil domain containing 111 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5695 Neighboring gene STARR-positive B cell enhancer ABC_E4274 Neighboring gene STARR-seq mESC enhancer starr_45930 Neighboring gene STARR-seq mESC enhancer starr_45932 Neighboring gene STARR-seq mESC enhancer starr_45936 Neighboring gene STARR-seq mESC enhancer starr_45939 Neighboring gene STARR-positive B cell enhancer ABC_E9456 Neighboring gene Sgms1 opposite strand transcript 1 Neighboring gene predicted gene, 38616 Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC30540

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in Golgi membrane  
    located_in Golgi membrane  
    located_in Golgi membrane PubMed 
    located_in Golgi trans cisterna PubMed 
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum membrane  
    located_in nucleus PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    phosphatidylcholine:ceramide cholinephosphotransferase 1
    Names
    protein Mob
    transmembrane protein 23
    NP_001161997.1
    NP_001161998.1
    NP_001349352.1
    NP_659041.3
    XP_006526881.1
    XP_006526882.1
    XP_006526883.1
    XP_011245504.1
    XP_011245505.1
    XP_011245507.1
    XP_017173594.1
    XP_030106691.1
    XP_030106692.1
    XP_030106693.1
    XP_030106695.1
    XP_030106696.1
    XP_030106697.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168525.1NP_001161997.1  phosphatidylcholine:ceramide cholinephosphotransferase 1

      See identical proteins and their annotated locations for NP_001161997.1

      Status: VALIDATED

      Source sequence(s)
      BC076618, BP768024
      Consensus CDS
      CCDS29750.1
      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Related
      ENSMUSP00000117336.2, ENSMUST00000142618.8
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    2. NM_001168526.1NP_001161998.1  phosphatidylcholine:ceramide cholinephosphotransferase 1

      See identical proteins and their annotated locations for NP_001161998.1

      Status: VALIDATED

      Source sequence(s)
      AC113485, AK146782, AK152312, BP768024
      Consensus CDS
      CCDS29750.1
      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Related
      ENSMUSP00000123395.2, ENSMUST00000151289.9
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    3. NM_001362423.1NP_001349352.1  phosphatidylcholine:ceramide cholinephosphotransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC113485, AC115752, AC124323, AC158130, BP768024
      Consensus CDS
      CCDS29750.1
      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    4. NM_144792.5NP_659041.3  phosphatidylcholine:ceramide cholinephosphotransferase 1

      See identical proteins and their annotated locations for NP_659041.3

      Status: VALIDATED

      Source sequence(s)
      AC115752, AK146782, AK153406, BP768024
      Consensus CDS
      CCDS29750.1
      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Related
      ENSMUSP00000097114.4, ENSMUST00000099514.10
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      32100127..32367285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247202.3XP_011245504.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245504.1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    2. XM_030250831.2XP_030106691.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    3. XM_030250836.2XP_030106696.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    4. XM_030250833.2XP_030106693.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    5. XM_030250832.1XP_030106692.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    6. XM_030250837.1XP_030106697.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    7. XM_011247203.3XP_011245505.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245505.1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    8. XM_006526819.3XP_006526882.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006526882.1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    9. XM_006526818.5XP_006526881.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006526881.1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    10. XM_030250835.1XP_030106695.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    11. XM_006526820.5XP_006526883.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006526883.1

      UniProtKB/Swiss-Prot
      Q3UIS8, Q5J3R0, Q8C464, Q8C583, Q8C652, Q8VCQ6
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    12. XM_011247205.3XP_011245507.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A494BA77
      Conserved Domains (1) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
    13. XM_017318105.3XP_017173594.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      E3W996
      Related
      ENSMUSP00000119869.2, ENSMUST00000152340.8
      Conserved Domains (1) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase

    RNA

    1. XR_001782565.2 RNA Sequence

    2. XR_001782566.2 RNA Sequence

    3. XR_004940129.1 RNA Sequence

    4. XR_004940128.1 RNA Sequence

    5. XR_003952767.2 RNA Sequence

    6. XR_003952764.2 RNA Sequence

    7. XR_003952765.2 RNA Sequence

      Related
      ENSMUST00000236410.2
    8. XR_003952766.2 RNA Sequence

    External link. Please review our privacy policy.