Atad2 ATPase family, AAA domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atad2provided by MGI
Official Full Name: ATPase family, AAA domain containing 2provided by MGI
Primary source: MGI:MGI:1917722
See related: Ensembl:ENSMUSG00000022360 AllianceGenome:MGI:1917722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610509G12Rik
Summary: Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Predicted to be involved in chromatin remodeling and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; salivary gland; and spleen. Orthologous to human ATAD2 (ATPase family AAA domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 11.8), CNS E11.5 (RPKM 11.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 24.32 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (57957440..57998516, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (58094044..58135525, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATAD2 controls chromatin-bound HIRA turnover.
Title: ATAD2 controls chromatin-bound HIRA turnover.
ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
Title: ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
Title: Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
Results found that ATAD2 is highly expressed in hepatocellular carcinoma tissues and could affect the expression of hedghog pathway.
Title: Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma.
EZH2 and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development.
Title: Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492062

Atad2 (e-PCR), detects polymorphism
- UniSTS:532536

Atad2 (e-PCR), detects polymorphism
- UniSTS:532537

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:488817

NoName (e-PCR)
- UniSTS:494200

NoName (e-PCR)
- UniSTS:237298

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATPase family AAA domain-containing protein 2

NP_001391691.1

EC 3.6.1.3

NP_001391693.1

EC 3.6.1.3

NP_001391694.1

EC 3.6.1.3

NP_001391695.1

EC 3.6.1.3

NP_081711.2

EC 3.6.1.3

XP_036015476.1

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404762.1 → NP_001391691.1 ATPase family AAA domain-containing protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC113292
NM_001404764.1 → NP_001391693.1 ATPase family AAA domain-containing protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC113292
NM_001404765.1 → NP_001391694.1 ATPase family AAA domain-containing protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC113292

UniProtKB/Swiss-Prot

Q3UYW6, Q8CDM1

Related

ENSMUSP00000153936.2, ENSMUST00000228783.2
NM_001404766.1 → NP_001391695.1 ATPase family AAA domain-containing protein 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC113292
NM_027435.3 → NP_081711.2 ATPase family AAA domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_081711.2

Status: VALIDATED

Source sequence(s)

AC113292

Consensus CDS

CCDS37079.1

UniProtKB/TrEMBL

G3X963

Related

ENSMUSP00000043691.4, ENSMUST00000038194.5

Conserved Domains (3) summary

cd05528
Location:960 → 1070

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:438 → 579

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:443 → 577

AAA; ATPase family associated with various cellular activities (AAA)

RNA

NR_175863.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113292

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

57957440..57998516 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159583.1 → XP_036015476.1 ATPase family AAA domain-containing protein 2 isoform X1

Conserved Domains (4) summary

cd05528
Location:459 → 569

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

COG0464
Location:3 → 406

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

TIGR01243
Location:3 → 172

CDC48; AAA family ATPase, CDC48 subfamily

cl38936
Location:1 → 74

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_153199.1: Suppressed sequence

Description

NM_153199.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.