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    CPA3 carboxypeptidase A3 [ Homo sapiens (human) ]

    Gene ID: 1359, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CPA3provided by HGNC
    Official Full Name
    carboxypeptidase A3provided by HGNC
    Primary source
    HGNC:HGNC:2298
    See related
    Ensembl:ENSG00000163751 MIM:114851; AllianceGenome:HGNC:2298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MC-CPA
    Summary
    This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in gall bladder (RPKM 74.3), lung (RPKM 46.6) and 11 other tissues See more
    Orthologs
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    Genomic context

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    See CPA3 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (148865296..148897203)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (151616046..151647965)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148583083..148614990)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase B1 Neighboring gene uncharacterized LOC107986045 Neighboring gene NANOG hESC enhancer GRCh37_chr3:148675298-148675799 Neighboring gene ubiquilin 4 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin. Soria-Castro R, et al. J Leukoc Biol, 2021 Sep. PMID 34057753, Free PMC Article
    2. Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy. Natsuaki M, et al. J Invest Dermatol, 1992 Aug. PMID 1629626
    3. Cloning and characterization of the novel gene for mast cell carboxypeptidase A. Reynolds DS, et al. J Clin Invest, 1992 Jan. PMID 1729276, Free PMC Article
    4. Detection and partial characterization of a human mast cell carboxypeptidase. Goldstein SM, et al. J Immunol, 1987 Oct 15. PMID 2443571
    5. Processing of procarboxypeptidase A and other zymogens in murine mast cells. Dikov MM, et al. J Biol Chem, 1994 Oct 14. PMID 7929294

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin.
      Title: Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin.
    2. Decreased serum level of carboxypeptidase is a hallmark of more advanced coronary artery disease.
      Title: Mast cell derived carboxypeptidase A3 is decreased among patients with advanced coronary artery disease.
    3. Carboxypeptidase A3 was differentially expressed between Fibromyalgia patients and healthy controls.
      Title: Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.
    4. Urine CPA3 was increased in patients with chronic prostatitis/chronic pelvic pain syndrome compared to controls.
      Title: Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.
    5. Role in regulating innate immunity responses and regulating secretory granule homeostasis
      Title: Novel insights into the biological function of mast cell carboxypeptidase A.
    6. The cDNA encoding human colon mast cell carboxypeptidase can be successfully cloned and expressed in E. coli and P. pastoris.
      Title: Cloning and expression of human colon mast cell carboxypeptidase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metallocarboxypeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of angiotensin levels in blood IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mast cell carboxypeptidase A
    Names
    carboxypeptidase A3 (mast cell)
    tissue carboxypeptidase A
    NP_001861.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001870.4 → NP_001861.2  mast cell carboxypeptidase A preproprotein

      See identical proteins and their annotated locations for NP_001861.2

      Status: REVIEWED

      Source sequence(s)
      AC092979, BC012613, BG501260, BX105358, DR005288, M27717
      Consensus CDS
      CCDS3138.1
      UniProtKB/Swiss-Prot
      P15088, Q96E94
      UniProtKB/TrEMBL
      B2R941
      Related
      ENSP00000296046.3, ENST00000296046.4
      Conserved Domains (2) summary
      cd03871
      Location:114 → 413
      M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
      pfam02244
      Location:28 → 102
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      148865296..148897203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      151616046..151647965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15088.2 GenPept UniProtKB/Swiss-Prot:P15088

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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