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    Tgm2 transglutaminase 2, C polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 21817, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tgm2provided by MGI
    Official Full Name
    transglutaminase 2, C polypeptideprovided by MGI
    Primary source
    MGI:MGI:98731
    See related
    Ensembl:ENSMUSG00000037820 AllianceGenome:MGI:98731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TG2; tTG; G[a]h; tTGas; TGase2
    Summary
    Enables protein-glutamine gamma-glutamyltransferase activity. Involved in intracellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 134.3), lung adult (RPKM 130.8) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tgm2 in Genome Data Viewer
    Location:
    2 H1; 2 78.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157958325..157988312, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158116405..158146392, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene regulation of nuclear pre-mRNA domain containing 1B Neighboring gene RIKEN cDNA 2010009K17 gene Neighboring gene STARR-seq mESC enhancer starr_06227 Neighboring gene STARR-seq mESC enhancer starr_06228 Neighboring gene predicted gene, 34458 Neighboring gene STARR-seq mESC enhancer starr_06229 Neighboring gene RIKEN cDNA D630003M21 gene Neighboring gene RIKEN cDNA 1700060C20 gene Neighboring gene predicted gene, 34514

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables histone dopaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone dopaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone serotonyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone serotonyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide histaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide histaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide noradrenalinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-glutamine gamma-glutamyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-glutamine glutaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-glutamine glutaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic cell clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dopamine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dopamine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to serotonin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to serotonin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide cross-linking ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptide cross-linking TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of small GTPase mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deamination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deamination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic cell clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within salivary gland cavitation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-glutamine gamma-glutamyltransferase 2
    Names
    C polypeptide
    TG(C)
    TGC
    TGase C
    TGase II
    TGase-2
    isopeptidase TGM2
    protein-glutamine deamidase TGM2
    protein-glutamine dopaminyltransferase TGM2
    protein-glutamine histaminyltransferase TGM2
    protein-glutamine noradrenalinyltransferase TGM2
    protein-glutamine serotonyltransferase TGM2
    protein-glutamine-gamma-glutamyltransferase
    tissue transglutaminase
    transglutaminase C
    transglutaminase II
    transglutaminase-2
    NP_033399.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009373.3NP_033399.1  protein-glutamine gamma-glutamyltransferase 2

      See identical proteins and their annotated locations for NP_033399.1

      Status: PROVISIONAL

      Source sequence(s)
      AL669824
      Consensus CDS
      CCDS16985.1
      UniProtKB/Swiss-Prot
      O88901, P21981, Q3TLV2, Q8C217, Q91VG9, Q9R1F7
      Related
      ENSMUSP00000099411.4, ENSMUST00000103122.10
      Conserved Domains (4) summary
      smart00460
      Location:269361
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:273369
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:7120
      Transglut_N; Transglutaminase family
      pfam00927
      Location:473572
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157958325..157988312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)