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    Gp5 glycoprotein 5 platelet [ Mus musculus (house mouse) ]

    Gene ID: 14729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gp5provided by MGI
    Official Full Name
    glycoprotein 5 plateletprovided by MGI
    Primary source
    MGI:MGI:1096363
    See related
    Ensembl:ENSMUSG00000047953 AllianceGenome:MGI:1096363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GPV
    Summary
    Enables collagen binding activity. Involved in blood coagulation and megakaryocyte development. Acts upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Predicted to be located in cell surface. Predicted to be part of glycoprotein Ib-IX-V complex. Is expressed in several structures, including hepatic primordium; liver; mesenchyme derived from splanchnopleure; placenta; and yolk sac. Orthologous to human GP5 (glycoprotein V platelet). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 14.8), liver E14.5 (RPKM 6.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gp5 in Genome Data Viewer
    Location:
    16 B2; 16 21.26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30126503..30129599, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30307685..30310781, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene carboxypeptidase N, polypeptide 2 Neighboring gene leucine rich repeat containing 15 Neighboring gene ATPase type 13A3 Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30389389-30389616 Neighboring gene STARR-seq mESC enhancer starr_40576 Neighboring gene STARR-seq mESC enhancer starr_40579 Neighboring gene transmembrane protein 44 Neighboring gene predicted gene, 52252

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain. Nonne C, et al. J Thromb Haemost, 2008 Jan. PMID 17988230
    2. Cloning and characterization of the gene encoding the murine glycoprotein V: the conserved thrombin-cleavable protein on platelet surface. Katsutani S, et al. Thromb Res, 1998 Oct 1. PMID 9783673
    3. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Kahn ML, et al. Blood, 1999 Dec 15. PMID 10590056
    4. Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. Moog S, et al. Blood, 2001 Aug 15. PMID 11493449
    5. Increased thrombogenesis and embolus formation in mice lacking glycoprotein V. Ni H, et al. Blood, 2001 Jul 15. PMID 11435305

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV for MP-dependent cleavage.
      Title: Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.
    2. ROLE OF GPV IN HEMOSTASIS AND THROMBOSIS IS PROBABLY OF LESSER IMPORTANCE THAN PREVIOUSLY THOUGHT
      Title: Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain.
    3. GPV is cleaved upon agonist-induced platelet activation, with ADAM17 as the major enzyme mediating this process
      Title: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.
    4. GPIbalpha and GPV are shed through an ADAM17-dependent mechanism after aspirin administration
      Title: Aspirin induces platelet receptor shedding via ADAM17 (TACE).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood coagulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood coagulation, intrinsic pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in megakaryocyte development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycoprotein Ib-IX-V complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycoprotein Ib-IX-V complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet glycoprotein V

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008148.4 → NP_032174.2  platelet glycoprotein V precursor

      See identical proteins and their annotated locations for NP_032174.2

      Status: VALIDATED

      Source sequence(s)
      AK031272, BE948546, BY235812
      Consensus CDS
      CCDS28100.1
      UniProtKB/TrEMBL
      Q3TA66, Q9QZU3
      Related
      ENSMUSP00000051895.7, ENSMUST00000061190.8
      Conserved Domains (4) summary
      cd00116
      Location:126 → 402
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:100 → 123
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:124 → 182
      LRR_8; Leucine rich repeat
      cl15307
      Location:421 → 454
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30126503..30129599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08742.1 GenPept UniProtKB/Swiss-Prot:O08742

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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