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    Mospd2 motile sperm domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 76763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mospd2provided by MGI
    Official Full Name
    motile sperm domain containing 2provided by MGI
    Primary source
    MGI:MGI:1924013
    See related
    Ensembl:ENSMUSG00000061778 AllianceGenome:MGI:1924013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410013I23Rik
    Summary
    Predicted to enable FFAT motif binding activity. Predicted to be involved in lipid droplet formation; positive regulation of leukocyte chemotaxis; and protein homooligomerization. Predicted to be located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. Predicted to be active in endomembrane system and endoplasmic reticulum-endosome membrane contact site. Is expressed in Meckel's cartilage and skeleton. Orthologous to human MOSPD2 (motile sperm domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 8.6), limb E14.5 (RPKM 5.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mospd2 in Genome Data Viewer
    Location:
    X F5; X 76.75 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (163719165..163763501, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164936169..164980505, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 9 Neighboring gene STARR-seq mESC enhancer starr_48241 Neighboring gene STARR-seq mESC enhancer starr_48242 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48243 Neighboring gene STARR-positive B cell enhancer mm9_chrX:161418402-161418703 Neighboring gene STARR-seq mESC enhancer starr_48245 Neighboring gene macrophage migration inhibitory factor, pseudogene 13 Neighboring gene Fanconi anemia, complementation group B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MOSPD2 is a therapeutic target for the treatment of CNS inflammation. Yacov N, et al. Clin Exp Immunol, 2020 Aug. PMID 32353176, Free PMC Article
    2. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
    3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
      Title: MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FFAT motif binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    motile sperm domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290523.1 → NP_001277452.1  motile sperm domain-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, which results in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK031405, AK035985, AL669950, AL732426
      Consensus CDS
      CCDS72467.1
      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Related
      ENSMUSP00000107867.3, ENSMUST00000112248.9
      Conserved Domains (2) summary
      pfam00635
      Location:327 → 431
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:93 → 234
      CRAL_TRIO; CRAL/TRIO domain

    2. NM_001290524.1 → NP_001277453.1  motile sperm domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001277453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, which results in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK031405, AK035985, AL669950, AL732426
      Consensus CDS
      CCDS72468.1
      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Related
      ENSMUSP00000107866.3, ENSMUST00000112247.9
      Conserved Domains (2) summary
      pfam00635
      Location:327 → 431
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:93 → 234
      CRAL_TRIO; CRAL/TRIO domain

    3. NM_029730.4 → NP_084006.2  motile sperm domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK031405, AK035985, AL669950, AL732426
      Consensus CDS
      CCDS53241.1
      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      UniProtKB/TrEMBL
      B1AU74
      Related
      ENSMUSP00000004715.2, ENSMUST00000004715.2
      Conserved Domains (2) summary
      pfam00635
      Location:327 → 431
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:93 → 234
      CRAL_TRIO; CRAL/TRIO domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      163719165..163763501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251516.1 → XP_030107376.1  motile sperm domain-containing protein 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Conserved Domains (2) summary
      pfam00635
      Location:335 → 439
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:101 → 242
      CRAL_TRIO; CRAL/TRIO domain

    2. XM_030251517.2 → XP_030107377.1  motile sperm domain-containing protein 2 isoform X7

      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Conserved Domains (2) summary
      pfam00635
      Location:335 → 439
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:101 → 242
      CRAL_TRIO; CRAL/TRIO domain

    3. XM_011247875.3 → XP_011246177.1  motile sperm domain-containing protein 2 isoform X4

      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Conserved Domains (2) summary
      pfam00635
      Location:338 → 442
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:101 → 245
      CRAL_TRIO; CRAL/TRIO domain

    4. XM_011247876.3 → XP_011246178.1  motile sperm domain-containing protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Conserved Domains (2) summary
      pfam00635
      Location:338 → 442
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:101 → 245
      CRAL_TRIO; CRAL/TRIO domain

    5. XM_006528985.4 → XP_006529048.1  motile sperm domain-containing protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Conserved Domains (2) summary
      pfam00635
      Location:330 → 434
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:93 → 237
      CRAL_TRIO; CRAL/TRIO domain

    6. XM_011247874.3 → XP_011246176.1  motile sperm domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Conserved Domains (2) summary
      pfam00635
      Location:335 → 439
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:101 → 242
      CRAL_TRIO; CRAL/TRIO domain

    7. XM_011247873.3 → XP_011246175.1  motile sperm domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
      Conserved Domains (2) summary
      pfam00635
      Location:338 → 442
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:101 → 245
      CRAL_TRIO; CRAL/TRIO domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWP6.2 GenPept UniProtKB/Swiss-Prot:Q9CWP6

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