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    Abcc9 ATP-binding cassette, sub-family C member 9 [ Mus musculus (house mouse) ]

    Gene ID: 20928, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcc9provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family C member 9provided by MGI
    Primary source
    MGI:MGI:1352630
    See related
    Ensembl:ENSMUSG00000030249 AllianceGenome:MGI:1352630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sur2; SUR2A; SUR2B
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Expression
    Broad expression in heart adult (RPKM 24.1), bladder adult (RPKM 9.3) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abcc9 in Genome Data Viewer
    Location:
    6 G2; 6 74.35 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142533592..142648472, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142587862..142702766, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38920 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 8 Neighboring gene STARR-seq mESC enhancer starr_17709 Neighboring gene RIKEN cDNA 5330439B14 gene Neighboring gene STARR-seq mESC enhancer starr_17710 Neighboring gene STARR-positive B cell enhancer ABC_E10416 Neighboring gene predicted gene, 53249 Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase Neighboring gene predicted gene, 46981 Neighboring gene sulfotransferase family 6B, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled monoatomic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfonylurea receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfonylurea receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ATP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel diameter maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to ATP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to ATP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to chemical stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to potassium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within circulatory system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within coronary vasculature development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inorganic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oxygen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cation channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to ATP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to decreased oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to estrogen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to hydrogen sulfide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to peptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to potassium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vascular process in circulatory system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of inward rectifying potassium channel IEA
    Inferred from Electronic Annotation
    more info
     
    part_of inward rectifying potassium channel ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family C member 9
    Names
    ATP-binding cassette transporter sub-family C member 9
    ATP-binding cassette, sub-family C (CFTR/MRP), member 9
    sulfonylurea receptor 2
    sulfonylurea-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044720.2NP_001038185.1  ATP-binding cassette sub-family C member 9 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (d, also known as SUR2 delta17/39) has the same N- and C-termini but is shorter compared to isoform b. This RefSeq is based on data in PMID: 10224138.
      Source sequence(s)
      AC121611
      UniProtKB/TrEMBL
      E9PUE8
      Related
      ENSMUSP00000107401.2, ENSMUST00000111771.8
      Conserved Domains (4) summary
      TIGR00957
      Location:231525
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03288
      Location:12941533
      ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
      cd03290
      Location:669873
      ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
      cl00549
      Location:9821216
      ABC_membrane; ABC transporter transmembrane region
    2. NM_001310143.2NP_001297072.1  ATP-binding cassette sub-family C member 9 isoform e

      See identical proteins and their annotated locations for NP_001297072.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two exons in the 3' coding region, compared to variant 2. It encodes isoform e (also known as SUR2 delta17/40), which lacks an internal in-frame segment and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC121611
      Conserved Domains (1) summary
      TIGR00957
      Location:231530
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    3. NM_001410414.1NP_001397343.1  ATP-binding cassette sub-family C member 9 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC121611
    4. NM_001410415.1NP_001397344.1  ATP-binding cassette sub-family C member 9 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC121611
    5. NM_001410416.1NP_001397345.1  ATP-binding cassette sub-family C member 9 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC121611
    6. NM_011511.3NP_035641.1  ATP-binding cassette sub-family C member 9 isoform a

      See identical proteins and their annotated locations for NP_035641.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding region compared to variant 2. The resulting isoform (a, also known as SUR2B or SUR2-40) has a distinct C-terminus compared to isoform b.
      Source sequence(s)
      AC121611
      Consensus CDS
      CCDS39696.1
      UniProtKB/Swiss-Prot
      P70170
      Related
      ENSMUSP00000098390.3, ENSMUST00000100827.5
      Conserved Domains (1) summary
      TIGR00957
      Location:231543
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    7. NM_021041.3NP_066378.1  ATP-binding cassette sub-family C member 9 isoform b

      See identical proteins and their annotated locations for NP_066378.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes isoform b (also known as SUR2A or SUR2-39).
      Source sequence(s)
      AC121611
      Consensus CDS
      CCDS39699.1
      UniProtKB/Swiss-Prot
      O08902, O08920, P70170, P70171
      Related
      ENSMUSP00000084805.5, ENSMUST00000087527.11
      Conserved Domains (1) summary
      TIGR00957
      Location:231538
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    8. NM_021042.3NP_066379.2  ATP-binding cassette sub-family C member 9 isoform c

      See identical proteins and their annotated locations for NP_066379.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (c, also known as SUR2 delta14/39) has the same N- and C-termini but is shorter compared to isoform b.
      Source sequence(s)
      AC121611
      Consensus CDS
      CCDS39697.1
      UniProtKB/Swiss-Prot
      P70170
      Related
      ENSMUSP00000072914.6, ENSMUST00000073173.12
      Conserved Domains (4) summary
      TIGR00957
      Location:231503
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03288
      Location:12721511
      ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
      cd03290
      Location:635851
      ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
      cl00549
      Location:9601194
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142533592..142648472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506949.5XP_006507012.1  ATP-binding cassette sub-family C member 9 isoform X1

      See identical proteins and their annotated locations for XP_006507012.1

      UniProtKB/Swiss-Prot
      P70170
      Conserved Domains (1) summary
      TIGR00957
      Location:231543
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    2. XM_006506950.5XP_006507013.1  ATP-binding cassette sub-family C member 9 isoform X1

      See identical proteins and their annotated locations for XP_006507013.1

      UniProtKB/Swiss-Prot
      P70170
      Conserved Domains (1) summary
      TIGR00957
      Location:231543
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    3. XM_006506951.5XP_006507014.1  ATP-binding cassette sub-family C member 9 isoform X1

      See identical proteins and their annotated locations for XP_006507014.1

      UniProtKB/Swiss-Prot
      P70170
      Conserved Domains (1) summary
      TIGR00957
      Location:231543
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    4. XM_036166002.1XP_036021895.1  ATP-binding cassette sub-family C member 9 isoform X2

      UniProtKB/Swiss-Prot
      O08902, O08920, P70170, P70171
      Conserved Domains (1) summary
      TIGR00957
      Location:231538
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021043.1: Suppressed sequence

      Description
      NM_021043.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.