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    Arc activity regulated cytoskeletal-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 11838, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arcprovided by MGI
    Official Full Name
    activity regulated cytoskeletal-associated proteinprovided by MGI
    Primary source
    MGI:MGI:88067
    See related
    Ensembl:ENSMUSG00000022602 AllianceGenome:MGI:88067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mArc; Arc3.1; arg3.1
    Summary
    Predicted to enable mRNA binding activity and structural molecule activity. Involved in long-term memory; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic plasticity. Acts upstream of or within anterior/posterior pattern specification and endoderm development. Located in dendritic spine; membrane raft; and neuronal ribonucleoprotein granule. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; extraembryonic component; metanephros; pancreas mesenchyme; and retina. Orthologous to human ARC (activity regulated cytoskeleton associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 87.3), cortex adult (RPKM 49.3) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arc in Genome Data Viewer
    Location:
    15 D3; 15 34.25 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74540930..74544419, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74669081..74672570, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor B1 Neighboring gene STARR-seq mESC enhancer starr_38984 Neighboring gene STARR-seq mESC enhancer starr_38985 Neighboring gene maestro heat-like repeat family member 4 Neighboring gene STARR-seq mESC enhancer starr_38988 Neighboring gene STARR-seq mESC enhancer starr_38991 Neighboring gene predicted gene, 32994 Neighboring gene STARR-seq mESC enhancer starr_38994 Neighboring gene RIKEN cDNA 4933427E11 gene Neighboring gene jerky

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of long-term synaptic depression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated intercellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated intercellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in virus-like capsid IEA
    Inferred from Electronic Annotation
    more info
     
    located_in virus-like capsid ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activity-regulated cytoskeleton-associated protein
    Names
    ARC/ARG3.1
    activity-regulated gene 3.1 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276684.1NP_001263613.1  activity-regulated cytoskeleton-associated protein

      See identical proteins and their annotated locations for NP_001263613.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC118022, AK157822
      Consensus CDS
      CCDS37102.1
      UniProtKB/Swiss-Prot
      Q9ES15, Q9WV31
      Related
      ENSMUSP00000105636.4, ENSMUST00000110009.4
      Conserved Domains (1) summary
      pfam18162
      Location:278360
      Arc_C; Arc C-lobe
    2. NM_018790.3NP_061260.1  activity-regulated cytoskeleton-associated protein

      See identical proteins and their annotated locations for NP_061260.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC118022, AF162777
      Consensus CDS
      CCDS37102.1
      UniProtKB/Swiss-Prot
      Q9ES15, Q9WV31
      Related
      ENSMUSP00000023268.7, ENSMUST00000023268.14
      Conserved Domains (1) summary
      pfam18162
      Location:278360
      Arc_C; Arc C-lobe

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      74540930..74544419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)