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    Zfp687 zinc finger protein 687 [ Mus musculus (house mouse) ]

    Gene ID: 78266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp687provided by MGI
    Official Full Name
    zinc finger protein 687provided by MGI
    Primary source
    MGI:MGI:1925516
    See related
    Ensembl:ENSMUSG00000019338 AllianceGenome:MGI:1925516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf687; mKIAA1441; 4931408L03Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and olfactory epithelium. Human ortholog(s) of this gene implicated in Paget's disease of bone 6. Orthologous to human ZNF687 (zinc finger protein 687). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.0), ovary adult (RPKM 11.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp687 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94901726..94923259, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94994674..95015948, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E231 Neighboring gene RIKEN cDNA B230398E01 gene Neighboring gene STARR-seq mESC enhancer starr_08361 Neighboring gene regulatory factor X, 5 (influences HLA class II expression) Neighboring gene STARR-positive B cell enhancer ABC_E652 Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene STARR-positive B cell enhancer ABC_E3449 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene microRNA 7013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94820548-94820749 Neighboring gene STARR-positive B cell enhancer ABC_E4560 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Neighboring gene STARR-seq mESC enhancer starr_08364 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Neighboring gene predicted gene, 24920

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Sánchez C, et al. Mol Cell Proteomics, 2007 May. PMID 17296600
    2. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article
    3. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 687

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357863.1 → NP_001344792.1  zinc finger protein 687

      Status: VALIDATED

      Source sequence(s)
      AC087062
      Consensus CDS
      CCDS17600.1
      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Related
      ENSMUST00000147022.8
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    2. NM_030074.3 → NP_084350.1  zinc finger protein 687

      See identical proteins and their annotated locations for NP_084350.1

      Status: VALIDATED

      Source sequence(s)
      AK019851, AK129360
      Consensus CDS
      CCDS17600.1
      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Related
      ENSMUSP00000019482.2, ENSMUST00000019482.8
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      94901726..94923259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252898.2 → XP_030108758.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    2. XM_036163410.1 → XP_036019303.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    3. XM_036163408.1 → XP_036019301.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    4. XM_036163409.1 → XP_036019302.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    5. XM_030252894.1 → XP_030108754.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    6. XM_036163407.1 → XP_036019300.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    7. XM_036163405.1 → XP_036019298.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    8. XM_036163406.1 → XP_036019299.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    9. XM_030252893.2 → XP_030108753.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    10. XM_006502307.4 → XP_006502370.1  zinc finger protein 687 isoform X1

      See identical proteins and their annotated locations for XP_006502370.1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type

    11. XM_030252895.2 → XP_030108755.1  zinc finger protein 687 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAP3, Q6ZPQ9, Q9D2D7
      Conserved Domains (5) summary
      PHA03247
      Location:169 → 532
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:30 → 281
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00017
      Location:966 → 986
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795 → 877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:1131 → 1159
      zf-C2H2_11; zinc-finger C2H2-type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2D7.1 GenPept UniProtKB/Swiss-Prot:Q9D2D7

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