Fasn fatty acid synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fasnprovided by RGD
Official Full Name: fatty acid synthaseprovided by RGD
Primary source: RGD:620665
See related: EnsemblRapid:ENSRNOG00000045636 AllianceGenome:RGD:620665
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables [acyl-carrier-protein] S-malonyltransferase activity; fatty acid synthase activity; and identical protein binding activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and response to nutrient. Located in cytoplasm. Biomarker of metabolic dysfunction-associated steatotic liver disease. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 3070.2), Thymus (RPKM 3061.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106570415..106588581, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (106072093..106090259, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109987735..110005901, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

2-Deoxy-D-Glucose Downregulates Fatty Acid Synthase Gene Expression Via an Endoplasmic Reticulum Stress-Dependent Pathway in HeLa Cells.
Title: 2-Deoxy-D-Glucose Downregulates Fatty Acid Synthase Gene Expression Via an Endoplasmic Reticulum Stress-Dependent Pathway in HeLa Cells.
Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Title: Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Fatty acid synthase (Fasn) inhibits the expression levels of immune response genes via alteration of alternative splicing in islet cells.
Title: Fatty acid synthase (Fasn) inhibits the expression levels of immune response genes via alteration of alternative splicing in islet cells.
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension revealed by inhibition of FASN. Inhibition of FAS decreases Right ventricle hypertrophy and improves cardiac function associated with Pulmonary hypertension by perking up metabolic functions.
Title: Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance
Title: Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
Calorie restriction during pregnancy modified the hepatic Fasn mRNA transcript level and altered the blood cholesterol concentrations in dams, but there were no such effects in their four-week-old offspring.
Title: Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn gene expression and methylation profiles in rats.
The involvement of SREBP-1c and ChREBP in FASN promoter histone modification.Histone acetylation affects FASN transcription by influencing ChREBP-binding carbohydrate-responsive elements.
Title: Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD.
This study showed that an associated inhibition of peroxisomal proliferator activated receptor gamma coactivator 1alpha (PGC1alpha), increased fatty acid synthase (FASN) expression in the liver, and reduced adipocyte triglyceride lipase (ATGL) expression.
Title: Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams.
Data suggest expression of Fas in liver can be regulated by dietary components; dietary fructose up-regulates expression of Fas; supplementation with citrulline prevents up-regulation of Fas, insulin resistance, and nonalcoholic fatty liver disease.
Title: Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats.
Results show that genes with the highest expression in the mammary gland, liver and adipose tissue were Elovl5, Fads2, and Fasn, respectively, in a low-lipid diet than in adequate-lipid diet.
Title: Role of maternal tissue in the synthesis of polyunsaturated fatty acids in response to a lipid-deficient diet during pregnancy and lactation in rats.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156147P10 (e-PCR)
- UniSTS:271369

PMC207565P2 (e-PCR)
- UniSTS:271952

RH141092 (e-PCR)
- UniSTS:223090

RH129091 (e-PCR)
- UniSTS:212399

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info
enables [acyl-carrier-protein] S-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables [acyl-carrier-protein] S-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables [acyl-carrier-protein] S-malonyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables fatty acid synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid synthase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid synthase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-[ACP] hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial intestinal barrier	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
involved_in ether lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ether lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glandular epithelial cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glandular epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in mammary gland development	IEA Inferred from Electronic Annotation more info
involved_in mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil differentiation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in glycogen granule	IEA Inferred from Electronic Annotation more info
located_in glycogen granule	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fatty acid synthase

Names: type I FAS

NP_059028.2

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017332.2 → NP_059028.2 fatty acid synthase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O09187, O09190, P12785, Q63577, Q64717

UniProtKB/TrEMBL

A0A8I6A2Z2, A6HLK3

Related

ENSRNOP00000064445.1, ENSRNOT00000073321.4

Conserved Domains (9) summary

cd08954
Location:1870 → 2106

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00829
Location:1558 → 1848

PKS_ER; Enoylreductase

PRK10252
Location:2121 → 2318

entF; enterobactin non-ribosomal peptide synthetase EntF

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam00698
Location:493 → 809

Acyl_transf_1; Acyl transferase domain

pfam00975
Location:2236 → 2495

Thioesterase; Thioesterase domain

pfam08242
Location:1238 → 1337

Methyltransf_12; Methyltransferase domain

pfam16197
Location:362 → 472

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:874 → 1109

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...