Pde10a phosphodiesterase 10A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pde10aprovided by RGD
Official Full Name: phosphodiesterase 10Aprovided by RGD
Primary source: RGD:68434
See related: EnsemblRapid:ENSRNOG00000011310 AllianceGenome:RGD:68434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pde10a3
Summary: Enables cyclic-nucleotide phosphodiesterase activity. Involved in cAMP catabolic process and cGMP catabolic process. Located in cytosol and perikaryon. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Biomarker of traumatic brain injury. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 161.1), Adrenal (RPKM 82.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (54313343..54765668, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (51765743..52218086, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (52360296..52544448, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease Therapy.
Title: Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease Therapy.
cAMP signaling pathway-related proteins, Pde10a and Gnal, may play important roles in the pathogenesis and recovery of mild traumatic brain injury.
Title: Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury.
Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents
Title: Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum.
analysis of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia in the rat model
Title: Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Dopamine loss inversely regulates PDE10A gene expression in the striatum and PDE10A post-transcription in the nucleus accumbens, therein differentially modulating PDE10A-dependent cyclic AMP catabolism.
Title: PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology.
Data show that pyridinyl derivatives were less potent than their quinolinyl counterparts, but still exhibited significant PDE10A inhibition potency.
Title: Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.
The present study is the first to demonstrate a central role of PDE10A in progressive pulmonary vascular remodeling.
Title: Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.
The findings presented suggest a role of PDE10A in the adaptation of cyclic nucleotide signaling to daily changes in light intensity in retinal neurons including photoreceptors
Title: Phosphodiesterase10A: abundance and circadian regulation in the retina and photoreceptor of the rat.
We here present, for the first time, the expression of PDE9A, PDE10A, and PDE11A in the trigeminovascular system; localisation indicates that they may have a role in pain pathways
Title: PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system.
The expression of Pde10a increases at night in the rat pineal gland >10-fold, where expression is controlled by an adrenergic/cyclic AMP mechanism.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE121313 (e-PCR)
- UniSTS:248064

D17Mit247 (e-PCR), detects polymorphism
- UniSTS:128059

BE097292 (e-PCR)
- UniSTS:244632

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cGMP binding	IEA Inferred from Electronic Annotation more info
enables cyclic-nucleotide phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cGMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Names: testis-specific phosphodiesterase PDE10A2

NP_001375438.1

EC 3.1.4.17

NP_001375439.1

EC 3.1.4.17

NP_001375440.1

EC 3.1.4.17

NP_071572.1

EC 3.1.4.17

XP_038945075.1

EC 3.1.4.17

XP_038945082.1

EC 3.1.4.17

XP_038945088.1

EC 3.1.4.17

XP_038945099.1

EC 3.1.4.17

XP_038945105.1

EC 3.1.4.17

XP_038945109.1

EC 3.1.4.17

XP_038945112.1

EC 3.1.4.17

XP_038945116.1

EC 3.1.4.17

XP_038945119.1

EC 3.1.4.17

XP_063128650.1

EC 3.1.4.17

XP_063128652.1

EC 3.1.4.17

XP_063128660.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001388509.1 → NP_001375438.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6KK15, A6KK18

Conserved Domains (3) summary

smart00065
Location:271 → 426

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:518 → 750

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:95 → 238

GAF; GAF domain
NM_001388510.1 → NP_001375439.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6KK15, A6KK18

Related

ENSRNOP00000107322.1, ENSRNOT00000160109.1

Conserved Domains (3) summary

smart00065
Location:271 → 426

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:518 → 750

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:95 → 238

GAF; GAF domain
NM_001388511.1 → NP_001375440.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6A4Q3

Related

ENSRNOP00000086886.1, ENSRNOT00000106865.2

Conserved Domains (3) summary

smart00065
Location:197 → 352

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:444 → 676

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:21 → 164

GAF; GAF domain
NM_022236.2 → NP_071572.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1

See identical proteins and their annotated locations for NP_071572.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q6S9E6, Q6S9E7, Q6S9E8, Q6S9E9, Q9QYJ5, Q9QYJ6

UniProtKB/TrEMBL

A0A8I6G6I2

Related

ENSRNOP00000104055.1, ENSRNOT00000141864.1

Conserved Domains (3) summary

smart00065
Location:277 → 432

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:524 → 756

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:101 → 244

GAF; GAF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

54313343..54765668 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089171.2 → XP_038945099.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5

UniProtKB/TrEMBL

A0A8I6AI39, A6KK14

Conserved Domains (3) summary

smart00065
Location:334 → 489

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:581 → 813

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:158 → 301

GAF; GAF domain
XM_039089160.2 → XP_038945088.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

UniProtKB/TrEMBL

A0A8I6AI39

Related

ENSRNOP00000091632.1, ENSRNOT00000111873.2

Conserved Domains (3) summary

smart00065
Location:335 → 490

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:582 → 814

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:159 → 302

GAF; GAF domain
XM_063272590.1 → XP_063128660.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_063272582.1 → XP_063128652.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2
XM_039089147.2 → XP_038945075.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

Conserved Domains (3) summary

smart00065
Location:558 → 713

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:805 → 1037

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:382 → 525

GAF; GAF domain
XM_063272580.1 → XP_063128650.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1
XM_039089154.2 → XP_038945082.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

Related

ENSRNOP00000108193.1, ENSRNOT00000172789.1

Conserved Domains (3) summary

smart00065
Location:558 → 713

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:805 → 1037

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:382 → 525

GAF; GAF domain
XM_039089184.2 → XP_038945112.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

UniProtKB/TrEMBL

A0A8I6A4Q3

Conserved Domains (3) summary

smart00065
Location:197 → 352

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:444 → 676

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:21 → 164

GAF; GAF domain
XM_039089177.2 → XP_038945105.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6

UniProtKB/TrEMBL

A6KK17, A6KK18, F1LX13

Related

ENSRNOP00000086612.1, ENSRNOT00000102087.2

Conserved Domains (3) summary

smart00065
Location:260 → 415

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:507 → 739

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:84 → 227

GAF; GAF domain
XM_039089181.2 → XP_038945109.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

UniProtKB/TrEMBL

A0A8I6A4Q3

Conserved Domains (3) summary

smart00065
Location:197 → 352

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:444 → 676

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:21 → 164

GAF; GAF domain
XM_039089188.2 → XP_038945116.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

UniProtKB/TrEMBL

A0A8I6A4Q3

Conserved Domains (3) summary

smart00065
Location:197 → 352

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:444 → 676

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:21 → 164

GAF; GAF domain
XM_039089191.2 → XP_038945119.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X8

UniProtKB/TrEMBL

A0A8I6A4Q3

Conserved Domains (3) summary

smart00065
Location:136 → 291

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:383 → 615

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:5 → 103

GAF; GAF domain