Usp37 ubiquitin specific peptidase 37 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usp37provided by RGD
Official Full Name: ubiquitin specific peptidase 37provided by RGD
Primary source: RGD:2319715
See related: EnsemblRapid:ENSRNOG00000022720 AllianceGenome:RGD:2319715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and protein kinase binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 132.7), Thymus (RPKM 107.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (83467966..83567848, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76018863..76118732, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (81717626..81818421, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 37

Names: ubiquitin specific protease 37

NP_001414600.1

EC 3.4.19.12

XP_006245354.1

EC 3.4.19.12

XP_006245355.1

EC 3.4.19.12

XP_006245356.1

EC 3.4.19.12

XP_006245357.1

EC 3.4.19.12

XP_006245358.1

EC 3.4.19.12

XP_008765529.1

EC 3.4.19.12

XP_063122570.1

EC 3.4.19.12

XP_063122571.1

EC 3.4.19.12

XP_063122572.1

EC 3.4.19.12

XP_063122573.1

EC 3.4.19.12

XP_063122574.1

EC 3.4.19.12

XP_063122575.1

EC 3.4.19.12

XP_063122576.1

EC 3.4.19.12

XP_063122577.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427671.1 → NP_001414600.1 ubiquitin carboxyl-terminal hydrolase 37

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6GH62, D4ABE5

Related

ENSRNOP00000033308.1, ENSRNOT00000032719.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

83467966..83567848 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266507.1 → XP_063122577.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X6

UniProtKB/TrEMBL

A0A8I6GH62
XM_063266503.1 → XP_063122573.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X4

UniProtKB/TrEMBL

A0A8I6B2I8, A0A8I6GH62
XM_063266501.1 → XP_063122571.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X2

UniProtKB/TrEMBL

A0A8I6GH62
XM_008767307.4 → XP_008765529.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

See identical proteins and their annotated locations for XP_008765529.1

UniProtKB/TrEMBL

A0A8I6GH62, D4ABE5

Conserved Domains (3) summary

cd02257
Location:342 → 603

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 600

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_006245293.5 → XP_006245355.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

See identical proteins and their annotated locations for XP_006245355.1

UniProtKB/TrEMBL

A0A8I6GH62, D4ABE5

Conserved Domains (3) summary

cd02257
Location:342 → 603

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 600

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_063266500.1 → XP_063122570.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

UniProtKB/TrEMBL

A0A8I6GH62, D4ABE5
XM_063266506.1 → XP_063122576.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X6

UniProtKB/TrEMBL

A0A8I6GH62
XM_063266505.1 → XP_063122575.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X5

UniProtKB/TrEMBL

A0A8I6GH62
XM_063266502.1 → XP_063122572.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X3

UniProtKB/TrEMBL

A0A8I6GH62
XM_006245295.5 → XP_006245357.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X2

See identical proteins and their annotated locations for XP_006245357.1

UniProtKB/TrEMBL

A0A8I6GH62

Conserved Domains (3) summary

cd02257
Location:342 → 603

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 600

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_006245296.4 → XP_006245358.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X4

See identical proteins and their annotated locations for XP_006245358.1

UniProtKB/TrEMBL

A0A8I6B2I8, A0A8I6GH62

Related

ENSRNOP00000095391.1, ENSRNOT00000107297.2

Conserved Domains (3) summary

cd02257
Location:342 → 603

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 600

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_006245292.5 → XP_006245354.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

See identical proteins and their annotated locations for XP_006245354.1

UniProtKB/TrEMBL

A0A8I6GH62, D4ABE5

Conserved Domains (3) summary

cd02257
Location:342 → 603

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 600

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_063266504.1 → XP_063122574.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X4

UniProtKB/TrEMBL

A0A8I6B2I8, A0A8I6GH62
XM_006245294.5 → XP_006245356.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

See identical proteins and their annotated locations for XP_006245356.1

UniProtKB/TrEMBL

A0A8I6GH62, D4ABE5

Conserved Domains (3) summary

cd02257
Location:342 → 603

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 600

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37