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    Cdk2ap1 cyclin dependent kinase 2 associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13445, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdk2ap1provided by MGI
    Official Full Name
    cyclin dependent kinase 2 associated protein 1provided by MGI
    Primary source
    MGI:MGI:1202069
    See related
    Ensembl:ENSMUSG00000029394 AllianceGenome:MGI:1202069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p12; Doc1; ST19; Apc10; DORC1; doc-1; Cdkap1
    Summary
    Predicted to enable DNA polymerase binding activity. Acts upstream of or within face morphogenesis and in utero embryonic development. Predicted to be located in several cellular components, including chromatin; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of NuRD complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; dentate gyrus subgranular zone; and retina. Orthologous to human CDK2AP1 (cyclin dependent kinase 2 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 155.0), CNS E14 (RPKM 126.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdk2ap1 in Genome Data Viewer
    Location:
    5 F; 5 63.53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124483502..124492691, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124345439..124354628, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 9 Neighboring gene mitochondrial translation release factor in rescue Neighboring gene strawberry notch 1 Neighboring gene STARR-seq mESC enhancer starr_14338 Neighboring gene STARR-positive B cell enhancer ABC_E851 Neighboring gene lysine methyltransferase 5A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102310, MGC117818

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 2-associated protein 1
    Names
    CDK2 (cyclin-dependent kinase 2)-associated protein 1
    CDK2-associated protein 1
    deleted in oral cancer 1
    putative oral cancer suppressor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013812.2NP_038840.2  cyclin-dependent kinase 2-associated protein 1

      See identical proteins and their annotated locations for NP_038840.2

      Status: VALIDATED

      Source sequence(s)
      AA190126, AK004852, BE623061
      Consensus CDS
      CCDS39279.1
      UniProtKB/Swiss-Prot
      B2RV53, O35207, Q3SYK3, Q6ZWZ1
      Related
      ENSMUSP00000031341.5, ENSMUST00000031341.11
      Conserved Domains (1) summary
      pfam09806
      Location:61113
      CDK2AP; Cyclin-dependent kinase 2-associated protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124483502..124492691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)