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    Stk36 serine/threonine kinase 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301516, updated on 27-Nov-2024

    Summary

    Official Symbol
    Stk36provided by RGD
    Official Full Name
    serine/threonine kinase 36provided by RGD
    Primary source
    RGD:1307318
    See related
    EnsemblRapid:ENSRNOG00000016913 AllianceGenome:RGD:1307318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and transcription corepressor binding activity. Predicted to be involved in several processes, including axoneme assembly; positive regulation of smoothened signaling pathway; and regulation of DNA-binding transcription factor activity. Predicted to act upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 66.1), Lung (RPKM 29.1) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Stk36 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83625905..83652785)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76176922..76204423)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81880175..81908014)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 4 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene uncharacterized LOC134480595 Neighboring gene tubulin tyrosine ligase like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 36
    Names
    serine/threonine kinase 36 (fused homolog, Drosophila)
    NP_001167457.1
    XP_006245236.1
    XP_063123044.1
    XP_063123045.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173986.1NP_001167457.1  serine/threonine-protein kinase 36

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D3ZA65
      Related
      ENSRNOP00000022839.7, ENSRNOT00000022839.9
      Conserved Domains (2) summary
      smart00220
      Location:4254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83625905..83652785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245174.5XP_006245236.1  serine/threonine-protein kinase 36 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y8C3, D3ZA65
      Related
      ENSRNOP00000077934.1, ENSRNOT00000112437.2
      Conserved Domains (2) summary
      smart00220
      Location:4254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
    2. XM_063266974.1XP_063123044.1  serine/threonine-protein kinase 36 isoform X2

    3. XM_063266975.1XP_063123045.1  serine/threonine-protein kinase 36 isoform X3