S100a10 S100 calcium binding protein A10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100a10provided by RGD
Official Full Name: S100 calcium binding protein A10provided by RGD
Primary source: RGD:628655
See related: EnsemblRapid:ENSRNOG00000023226 AllianceGenome:RGD:628655
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p11
Summary: Predicted to enable several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in cell surface; membrane raft; and plasma membrane. Predicted to be part of AnxA2-p11 complex; RNA polymerase II transcription regulator complex; and plasma membrane protein complex. Predicted to be active in cytoplasm and extracellular space. Used to study depressive disorder. Biomarker of depressive disorder. Orthologous to human S100A10 (S100 calcium binding protein A10). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: In the RGSCv3.4 reference assembly (NC_005101.2 bases 186645170 to 186645549), an assembly gap exists in the putative promoter of s100a10; this gap has been filled by GenBank accession JN393207.1. [17 Jun 2014]
Expression: Biased expression in Lung (RPKM 849.9), Uterus (RPKM 665.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (181904454..181913101)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (179221012..179229659)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (193892589..193901236)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity.
Title: Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity.
S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.
Title: S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.
Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells.
Title: Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells.
Results suggest that there are breeder-dependent differences in vulnerability to stress in the chronic mild stress (CMS) model of depression, which might bear on the validity of the model and contribute to contradictory findings and difficulties of replication between laboratories. P11 mRNA expression seems to be differently regulated depending on the quality of the stress response evoked by CMS exposure.
Title: Behavioral differences of male Wistar rats from different vendors in vulnerability and resilience to chronic mild stress are reflected in epigenetic regulation and expression of p11.
The protein p11 is widely expressed in several brain regions that are implicated in the pathophysiology of depression.
Title: Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model.
Increased p11 expression by BDNF and imipramine unraveled a 5-HT4R-mediated modulation of cardiac Ca(2+) handling
Title: p11 modulates calcium handling through 5-HT₄R pathway in rat ventricular cardiomyocytes.
binding of p11 to TASK-1 retards the surface expression of the channel, most likely by virtue of a di-lysine retention signal at the C-terminus of p11
Title: The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1.
p11, already known to traffic members of the voltage-gated sodium and potassium channel families as well as transient receptor potential and chloride channels, also plays a selective role in enhancing ASIC1a functional expression
Title: Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a.
Binding domains of P11 interact with those in the sodium channel Na(V)1.8 intracellular N-terminal region.
Title: Identification of binding domains in the sodium channel Na(V)1.8 intracellular N-terminal region and annexin II light chain p11.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128467 (e-PCR)
- UniSTS:211775

S100a10 (e-PCR), detects polymorphism
- UniSTS:507204

S100a10 (e-PCR), detects polymorphism
- UniSTS:465493

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables lipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in membrane raft assembly	IEA Inferred from Electronic Annotation more info
involved_in membrane raft assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle budding from membrane	IEA Inferred from Electronic Annotation more info
involved_in vesicle budding from membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AnxA2-p11 complex	IEA Inferred from Electronic Annotation more info
part_of AnxA2-p11 complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	IEA Inferred from Electronic Annotation more info
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A10

Names: S-100 related protein, clone 42C; annexin II ligand; calpactin I light chain; calpactin-1 light chain; cellular ligand of annexin II; nerve growth factor-induced protein 42C; p10 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031114.1 → NP_112376.1 protein S100-A10

See identical proteins and their annotated locations for NP_112376.1

Status: PROVISIONAL

Source sequence(s)

J03627

UniProtKB/Swiss-Prot

P05943, Q5BJ98

UniProtKB/TrEMBL

A0A8L2QLC5, B3Y9H3

Related

ENSRNOP00000096575.1, ENSRNOT00000120014.2

Conserved Domains (1) summary

cl08302
Location:3 → 93

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...