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    Tmcc1 transmembrane and coiled-coil domain family 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmcc1provided by RGD
    Official Full Name
    transmembrane and coiled-coil domain family 1provided by RGD
    Primary source
    RGD:1311909
    See related
    EnsemblRapid:ENSRNOG00000011614 AllianceGenome:RGD:1311909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311909
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Predicted to be located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. Predicted to be active in endomembrane system. Orthologous to human TMCC1 (transmembrane and coiled-coil domain family 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 88.8), Muscle (RPKM 83.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmcc1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150738966..150912256, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149069252..149239585, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147920987..148048852, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene plexin D1 Neighboring gene H1.8 linker histone Neighboring gene small RNA binding exonuclease protection factor La like 1 Neighboring gene WASH complex subunit 2C Neighboring gene ribosomal protein L9, pseudogene 19 Neighboring gene zinc finger AN1-type containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission. Hoyer MJ, et al. Cell, 2018 Sep 20. PMID 30220460, Free PMC Article
    2. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. Zhang C, et al. PLoS One, 2014. PMID 24454821, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domains protein 1
    Names
    transmembrane and coiled coil domains 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427270.2 → NP_001414199.1  transmembrane and coiled-coil domains protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZH14
      Related
      ENSRNOP00000090083.2, ENSRNOT00000099557.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      150738966..150912256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286097.1 → XP_063142167.1  transmembrane and coiled-coil domains protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABR1

    2. XM_039109036.2 → XP_038964964.1  transmembrane and coiled-coil domains protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABR1
      Related
      ENSRNOP00000039858.4, ENSRNOT00000042418.8
      Conserved Domains (1) summary
      pfam10267
      Location:271 → 678
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_063286099.1 → XP_063142169.1  transmembrane and coiled-coil domains protein 1 isoform X2

      UniProtKB/TrEMBL
      D3ZH14

    4. XM_063286096.1 → XP_063142166.1  transmembrane and coiled-coil domains protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABR1

    5. XM_063286100.1 → XP_063142170.1  transmembrane and coiled-coil domains protein 1 isoform X2

      UniProtKB/TrEMBL
      D3ZH14

    6. XM_063286098.1 → XP_063142168.1  transmembrane and coiled-coil domains protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABR1

    7. XM_006237071.5 → XP_006237133.1  transmembrane and coiled-coil domains protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006237133.1

      UniProtKB/TrEMBL
      A0A8I6GKA4
      Related
      ENSRNOP00000098780.1, ENSRNOT00000127762.1
      Conserved Domains (1) summary
      pfam10267
      Location:52 → 459
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    8. XM_006237072.5 → XP_006237134.1  transmembrane and coiled-coil domains protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006237134.1

      UniProtKB/TrEMBL
      A0A8I6AFS3, A6IL07
      Related
      ENSRNOP00000092679.2, ENSRNOT00000099111.2
      Conserved Domains (1) summary
      pfam10267
      Location:51 → 455
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    9. XM_017593028.3 → XP_017448517.1  transmembrane and coiled-coil domains protein 1 isoform X3

    10. XM_063286102.1 → XP_063142172.1  transmembrane and coiled-coil domains protein 1 isoform X6

      UniProtKB/TrEMBL
      A6IL08
    Nucleotide Protein Strain
    Heading Accession and Version

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