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    Nr1h2 nuclear receptor subfamily 1, group H, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22260, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nr1h2provided by MGI
    Official Full Name
    nuclear receptor subfamily 1, group H, member 2provided by MGI
    Primary source
    MGI:MGI:1352463
    See related
    Ensembl:ENSMUSG00000060601 AllianceGenome:MGI:1352463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UR; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta
    Summary
    Enables chromatin DNA binding activity; nuclear receptor activity; and nuclear retinoid X receptor binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of transport; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 100.3), duodenum adult (RPKM 94.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nr1h2 in Genome Data Viewer
    Location:
    7 B3; 7 28.83 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44199040..44204928, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44549616..44553968, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053 Neighboring gene STARR-positive B cell enhancer ABC_E1339 Neighboring gene STARR-positive B cell enhancer ABC_E8170 Neighboring gene STARR-positive B cell enhancer ABC_E2234 Neighboring gene STARR-positive B cell enhancer ABC_E290 Neighboring gene napsin A aspartic peptidase Neighboring gene predicted gene 15396 Neighboring gene STARR-positive B cell enhancer ABC_E446 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables apolipoprotein A-I receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables apolipoprotein A-I receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol storage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of pinocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of pinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylcholine acyl-chain remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cholesterol efflux IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of high-density lipoprotein particle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of pancreatic juice secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of secretion of lysosomal enzymes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    oxysterols receptor LXR-beta
    Names
    LXR beta
    liver X receptor beta
    retinoid X receptor-interacting protein No.15
    ubiquitously-expressed nuclear receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285517.2NP_001272446.1  oxysterols receptor LXR-beta isoform a

      See identical proteins and their annotated locations for NP_001272446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC149607, AC157653
      Consensus CDS
      CCDS21211.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      A0A140LHL9
      Related
      ENSMUSP00000073188.6, ENSMUST00000073488.12
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    2. NM_001285518.2NP_001272447.1  oxysterols receptor LXR-beta isoform b

      See identical proteins and their annotated locations for NP_001272447.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AC149607, AC157653
      Consensus CDS
      CCDS71947.1
      UniProtKB/TrEMBL
      A0A140LHL9, Q8BP65
      Related
      ENSMUSP00000103543.2, ENSMUST00000107910.8
      Conserved Domains (2) summary
      cd06954
      Location:206441
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:55151
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    3. NM_001285519.2NP_001272448.1  oxysterols receptor LXR-beta isoform b

      See identical proteins and their annotated locations for NP_001272448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AC149607, AC157653
      Consensus CDS
      CCDS71947.1
      UniProtKB/TrEMBL
      A0A140LHL9, Q8BP65
      Related
      ENSMUSP00000103544.2, ENSMUST00000107911.8
      Conserved Domains (2) summary
      cd06954
      Location:206441
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:55151
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. NM_001416185.1NP_001403114.1  oxysterols receptor LXR-beta isoform a

      Status: VALIDATED

      Source sequence(s)
      AC149607, AC157653
      UniProtKB/Swiss-Prot
      Q60644
      Related
      ENSMUSP00000103545.2, ENSMUST00000107912.8
    5. NM_009473.4NP_033499.1  oxysterols receptor LXR-beta isoform a

      See identical proteins and their annotated locations for NP_033499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC149607, AC157653
      Consensus CDS
      CCDS21211.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      A0A140LHL9
      Related
      ENSMUSP00000126788.2, ENSMUST00000167197.8
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44199040..44204928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242378.2XP_030098238.1  oxysterols receptor LXR-beta isoform X2

      UniProtKB/TrEMBL
      A0A140LHL9
      Conserved Domains (2) summary
      cd06954
      Location:138373
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:183
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    2. XM_017322126.2XP_017177615.1  oxysterols receptor LXR-beta isoform X2

      UniProtKB/TrEMBL
      A0A140LHL9
      Conserved Domains (2) summary
      cd06954
      Location:138373
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:183
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers