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    Prps2 phosphoribosyl pyrophosphate synthetase 2 [ Mus musculus (house mouse) ]

    Gene ID: 110639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prps2provided by MGI
    Official Full Name
    phosphoribosyl pyrophosphate synthetase 2provided by MGI
    Primary source
    MGI:MGI:97776
    See related
    Ensembl:ENSMUSG00000025742 AllianceGenome:MGI:97776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prps-2; 2610101M19Rik
    Summary
    Enables ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process and pentose-phosphate shunt. Is active in cytosol. Is expressed in alimentary system; central nervous system; heart; liver; and retina. Orthologous to human PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.7), genital fat pad adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prps2 in Genome Data Viewer
    Location:
    X F5; X 78.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (166129316..166165887, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (167346320..167382872, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chrX:163766615-163766916 Neighboring gene STARR-seq mESC enhancer starr_48272 Neighboring gene STARR-seq mESC enhancer starr_48273 Neighboring gene STARR-seq mESC enhancer starr_48274 Neighboring gene toll-like receptor 8 Neighboring gene toll-like receptor 7 Neighboring gene predicted gene 15239 Neighboring gene predicted gene, 26368 Neighboring gene predicted gene 6744 Neighboring gene FERM and PDZ domain containing 4 Neighboring gene BTB (POZ) domain containing 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis. Lei B, et al. Asian J Androl, 2020 Sep-Oct. PMID 31736475, Free PMC Article
    2. PRPS2-mediated modulation of the antitumor immune response in lung cancer through CCL2-mediated tumor-associated macrophages and myeloid-derived suppressor cells. Liu Q, et al. Thorac Cancer, 2024 Aug. PMID 38952044, Free PMC Article
    3. PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells. Lei B, et al. J Urol, 2015 Nov. PMID 26004865
    4. Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript. Taira M, et al. Biochim Biophys Acta, 1989 Mar 1. PMID 2537655
    5. Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase. Zhang F, et al. Nat Commun, 2015 Jul 15. PMID 26175007, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRPS2-mediated modulation of the antitumor immune response in lung cancer through CCL2-mediated tumor-associated macrophages and myeloid-derived suppressor cells.
      Title: PRPS2-mediated modulation of the antitumor immune response in lung cancer through CCL2-mediated tumor-associated macrophages and myeloid-derived suppressor cells.
    2. Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis.
      Title: Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis.
    3. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway.
      Title: PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.
    4. Study demonstrates with a Prps2 knockout mouse that the nexus between protein and nucleotide biosynthesis controlled by PRPS2 is crucial for Myc-driven tumorigenesis.
      Title: Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28388

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribose phosphate diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose phosphate diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose phosphate diphosphokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribose phosphate diphosphokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribose phosphate diphosphokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribose phosphate diphosphokinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribose-phosphate pyrophosphokinase 2
    Names
    PRS-II
    phosphoribosyl pyrophosphate synthase II
    phosphoribosyl pyrophosphate synthetase II
    NP_001300687.1
    NP_080938.1
    XP_017173840.1
    XP_017173841.1
    XP_036017671.1
    XP_036017672.1
    XP_036017673.1
    XP_036017674.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313758.1 → NP_001300687.1  ribose-phosphate pyrophosphokinase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029690, AL731735, AV467400, BY127801, CF733337
      UniProtKB/TrEMBL
      Q3TI27, Q3UPD5
      Conserved Domains (3) summary
      COG0462
      Location:1 → 316
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
      pfam13793
      Location:4 → 123
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      cl00309
      Location:164 → 316
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    2. NM_026662.5 → NP_080938.1  ribose-phosphate pyrophosphokinase 2 isoform 2

      See identical proteins and their annotated locations for NP_080938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK029690, AL731735, AV467400, BY127801
      Consensus CDS
      CCDS30532.1
      UniProtKB/Swiss-Prot
      Q9CS42, Q9CZA9
      UniProtKB/TrEMBL
      Q3TI27, Q3UPD5
      Related
      ENSMUSP00000026839.5, ENSMUST00000026839.5
      Conserved Domains (3) summary
      COG0462
      Location:1 → 313
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
      pfam13793
      Location:4 → 120
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      cl00309
      Location:161 → 313
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      166129316..166165887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161779.1 → XP_036017672.1  ribose-phosphate pyrophosphokinase 2 isoform X2

      Conserved Domains (1) summary
      COG0462
      Location:189 → 461
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

    2. XM_036161778.1 → XP_036017671.1  ribose-phosphate pyrophosphokinase 2 isoform X1

      Conserved Domains (1) summary
      COG0462
      Location:189 → 464
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

    3. XM_036161781.1 → XP_036017674.1  ribose-phosphate pyrophosphokinase 2 isoform X4

      Conserved Domains (1) summary
      pfam13793
      Location:189 → 251
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

    4. XM_036161780.1 → XP_036017673.1  ribose-phosphate pyrophosphokinase 2 isoform X3

      Conserved Domains (1) summary
      pfam13793
      Location:189 → 250
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

    5. XM_017318352.3 → XP_017173841.1  ribose-phosphate pyrophosphokinase 2 isoform X6

      Conserved Domains (1) summary
      pfam13793
      Location:85 → 184
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

    6. XM_017318351.3 → XP_017173840.1  ribose-phosphate pyrophosphokinase 2 isoform X5

      Conserved Domains (1) summary
      pfam13793
      Location:85 → 183
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CS42.4 GenPept UniProtKB/Swiss-Prot:Q9CS42

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