Mt4 metallothionein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mt4provided by MGI
Official Full Name: metallothionein 4provided by MGI
Primary source: MGI:MGI:99692
See related: Ensembl:ENSMUSG00000031757 AllianceGenome:MGI:99692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MT-IV
Summary: Enables metal ion binding activity. Acts upstream of or within intracellular monoatomic cation homeostasis. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in decidua; decidua capsularis; embryo; liver; and tongue. Orthologous to human MT4 (metallothionein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 208.7) and lung adult (RPKM 100.3) See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.26 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (94863832..94865659)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94137204..94139031)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MT4 plays a physiological role related with copper requirements in epithelial differentiating tissues, where MT4 is expressed
Title: Functional differentiation in the mammalian metallothionein gene family: metal binding features of mouse MT4 and comparison with its paralog MT1.
analysis of metal-thiolate clusters in epithelium-specific metallothionein-4
Title: Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489087

Mt4 (e-PCR), detects polymorphism
- UniSTS:546512

U07808 (e-PCR)
- UniSTS:125657

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular monoatomic cation homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to cadmium ion	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: metallothionein-4

Names: MT-4; metallothionein-IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.