Esrrg estrogen-related receptor gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esrrgprovided by MGI
Official Full Name: estrogen-related receptor gammaprovided by MGI
Primary source: MGI:MGI:1347056
See related: Ensembl:ENSMUSG00000026610 AllianceGenome:MGI:1347056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERR3; Errg; NR3B3; mKIAA0832
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and estrogen response element binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 6.9), kidney adult (RPKM 4.9) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H5- H6; 1 91.83 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (187340707..187947082)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (187608510..188214885)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells.
Title: Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells.
ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
Title: ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
Upregulation of the ERRgamma-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
Title: Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
Estrogen-related receptor gamma (ERRgamma) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
Title: Estrogen-related receptor γ (ERRγ) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
Title: ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
Title: Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
Orphan nuclear receptor ERRgamma regulates hepatic TGF-beta2 expression and fibrogenic response in CCl4-induced acute liver injury.
Title: Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl(4)-induced acute liver injury.
Orphan nuclear receptor ERR-gamma regulates hepatic FGF23 production in acute kidney injury.
Title: Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.
Cardiac-Specific Overexpression of ERRgamma in Mice Induces Severe Heart Dysfunction and Early Lethality.
Title: Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality.
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
Title: A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit459 (e-PCR), detects polymorphism
- UniSTS:128829

UniSTS:495942 (e-PCR)
- UniSTS:495942

Esrrg (e-PCR), detects polymorphism
- UniSTS:495942

D1S506 (e-PCR)
- UniSTS:54122

WI-12511 (e-PCR)
- UniSTS:1717

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	NAS Non-traceable Author Statement more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables estrogen response element binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: estrogen-related receptor gamma

Names: estrogen receptor-related protein 3; estrogen-related receptor 3; nuclear receptor subfamily 3 group B member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243792.1 → NP_001230721.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230721.1

Status: VALIDATED

Source sequence(s)

AK052731, BC082324, BY067844

Consensus CDS

CCDS56666.1

UniProtKB/Swiss-Prot

P62509

Related

ENSMUSP00000106564.2, ENSMUST00000110939.8

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001357534.1 → NP_001344463.1 estrogen-related receptor gamma isoform 2

Status: VALIDATED

Source sequence(s)

AC109296, AC115061, AC116380, AC122122

Consensus CDS

CCDS56666.1

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001357535.1 → NP_001344464.1 estrogen-related receptor gamma isoform 2

Status: VALIDATED

Source sequence(s)

AC109296, AC115061, AC116380, AC122122

Consensus CDS

CCDS56666.1

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001357536.1 → NP_001344465.1 estrogen-related receptor gamma isoform 3

Status: VALIDATED

Source sequence(s)

AC116380, AC122122

Conserved Domains (2) summary

cd06946
Location:220 → 439

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:105 → 201

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_011935.3 → NP_036065.1 estrogen-related receptor gamma isoform 1

See identical proteins and their annotated locations for NP_036065.1

Status: VALIDATED

Source sequence(s)

BC082324, CJ062694

Consensus CDS

CCDS15606.1

UniProtKB/Swiss-Prot

P62509, Q8CHC9

Related

ENSMUSP00000027906.7, ENSMUST00000027906.13

Conserved Domains (2) summary

cd06946
Location:237 → 456

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:122 → 218

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

187340707..187947082

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238916.4 → XP_011237218.1 estrogen-related receptor gamma isoform X1

See identical proteins and their annotated locations for XP_011237218.1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_006497165.5 → XP_006497228.1 estrogen-related receptor gamma isoform X3

See identical proteins and their annotated locations for XP_006497228.1

UniProtKB/Swiss-Prot

P62509

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_036165240.1 → XP_036021133.1 estrogen-related receptor gamma isoform X3

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011238917.4 → XP_011237219.1 estrogen-related receptor gamma isoform X1

See identical proteins and their annotated locations for XP_011237219.1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011238920.4 → XP_011237222.1 estrogen-related receptor gamma isoform X1

See identical proteins and their annotated locations for XP_011237222.1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011238918.4 → XP_011237220.1 estrogen-related receptor gamma isoform X1

See identical proteins and their annotated locations for XP_011237220.1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011238915.4 → XP_011237217.1 estrogen-related receptor gamma isoform X1

See identical proteins and their annotated locations for XP_011237217.1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_030254422.2 → XP_030110282.1 estrogen-related receptor gamma isoform X1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_036165247.1 → XP_036021140.1 estrogen-related receptor gamma isoform X3

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011238919.4 → XP_011237221.1 estrogen-related receptor gamma isoform X1

See identical proteins and their annotated locations for XP_011237221.1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_036165239.1 → XP_036021132.1 estrogen-related receptor gamma isoform X3

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_036165237.1 → XP_036021130.1 estrogen-related receptor gamma isoform X1

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:111 → 207

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_036165242.1 → XP_036021135.1 estrogen-related receptor gamma isoform X3

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_036165250.1 → XP_036021143.1 estrogen-related receptor gamma isoform X3

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_006497170.3 → XP_006497233.1 estrogen-related receptor gamma isoform X3

See identical proteins and their annotated locations for XP_006497233.1

UniProtKB/Swiss-Prot

P62509

Related

ENSMUSP00000106563.2, ENSMUST00000110938.2

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_030254424.2 → XP_030110284.1 estrogen-related receptor gamma isoform X2

Conserved Domains (2) summary

cd06946
Location:224 → 443

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:109 → 205

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers