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    Trmt10b tRNA methyltransferase 10B [ Mus musculus (house mouse) ]

    Gene ID: 69934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmt10bprovided by MGI
    Official Full Name
    tRNA methyltransferase 10Bprovided by MGI
    Primary source
    MGI:MGI:1917184
    See related
    Ensembl:ENSMUSG00000035601 AllianceGenome:MGI:1917184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnmtd3; Rg9mtd3; 2610042J10Rik
    Summary
    Predicted to enable tRNA binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane and tRNA N1-guanine methylation. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in nucleoplasm. Orthologous to human TRMT10B (tRNA methyltransferase 10B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.1), CNS E11.5 (RPKM 4.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt10b in Genome Data Viewer
    Location:
    4 B1; 4 23.83 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45297158..45316181)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45297068..45316134)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene FERM and PDZ domain containing 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45309913-45310096 Neighboring gene exosome component 3 Neighboring gene predicted gene, 31017

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA (guanosine(9)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methyltransferase 10 homolog B
    Names
    RNA (guanine-9-) methyltransferase domain containing 3
    RNA (guanine-9-)-methyltransferase domain-containing protein 3
    tRNA (guanine(9)-N(1))-methyltransferase TRMT10B
    NP_001406121.1
    NP_001406122.1
    NP_001406123.1
    NP_001406124.1
    NP_081542.2
    XP_006538308.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419192.1 → NP_001406121.1  tRNA methyltransferase 10 homolog B isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772285
      UniProtKB/Swiss-Prot
      A2AKB5, A2AKB6, Q8VCR1, Q9D075

    2. NM_001419193.1 → NP_001406122.1  tRNA methyltransferase 10 homolog B isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772285
      UniProtKB/Swiss-Prot
      A2AKB5, A2AKB6, Q8VCR1, Q9D075

    3. NM_001419194.1 → NP_001406123.1  tRNA methyltransferase 10 homolog B isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772285
      UniProtKB/Swiss-Prot
      A2AKB5, A2AKB6, Q8VCR1, Q9D075

    4. NM_001419195.1 → NP_001406124.1  tRNA methyltransferase 10 homolog B isoform b

      Status: VALIDATED

      Source sequence(s)
      AL772285
      UniProtKB/TrEMBL
      Z4YKN9
      Related
      ENSMUSP00000103429.2, ENSMUST00000107800.3

    5. NM_027266.5 → NP_081542.2  tRNA methyltransferase 10 homolog B isoform a

      See identical proteins and their annotated locations for NP_081542.2

      Status: VALIDATED

      Source sequence(s)
      AL772285
      Consensus CDS
      CCDS18135.1
      UniProtKB/Swiss-Prot
      A2AKB5, A2AKB6, Q8VCR1, Q9D075
      Related
      ENSMUSP00000041052.3, ENSMUST00000044673.9
      Conserved Domains (1) summary
      cd18100
      Location:126 → 308
      Trm10euk_B; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B

    RNA

    1. NR_185032.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772285

    2. NR_185033.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772285

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45297158..45316181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538245.3 → XP_006538308.1  tRNA methyltransferase 10 homolog B isoform X2

      Conserved Domains (1) summary
      cd18100
      Location:63 → 245
      Trm10euk_B; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B

    RNA

    1. XR_004941955.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D075.2 GenPept UniProtKB/Swiss-Prot:Q9D075

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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