Aanat arylalkylamine N-acetyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aanatprovided by MGI
Official Full Name: arylalkylamine N-acetyltransferaseprovided by MGI
Primary source: MGI:MGI:1328365
See related: Ensembl:ENSMUSG00000020804 AllianceGenome:MGI:1328365
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nat4; Snat; Nat-2; AA-NAT
Summary: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 81.43 cM; 11 E2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116482547..116489022)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116591721..116597680)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
Title: The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
Report shows that the embryos synthesize melatonin by the enzyme Aanat which is located in the mitochondria.
Title: Aanat Knockdown and Melatonin Supplementation in Embryo Development: Involvement of Mitochondrial Function and DNA Methylation.
Inducing nighttime expression of Aanat facilitates nocturnal melatonin synthesis
Title: Circadian dynamics of the cone-rod homeobox (CRX) transcription factor in the rat pineal gland and its role in regulation of arylalkylamine N-acetyltransferase (AANAT).
analysis of regulation of AANAT gene expression in rats and Syrian hamsters [review]
Title: Rat and Syrian hamster: two models for the regulation of AANAT gene expression.
AANAT expression and synthesis of N-acetylserotonin/melatonin could play a role in addictive properties of cocaine
Title: Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Not Applicable (1) 1 citation
Spontaneous (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491292

D11Mit102 (e-PCR), detects polymorphism
- UniSTS:126289

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables aralkylamine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aralkylamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables aralkylamine N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables arylamine N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal protein amino acid acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in melatonin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in melatonin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in melatonin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in melatonin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in photoperiodism	IEA Inferred from Electronic Annotation more info
involved_in photoperiodism	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to copper ion	IEA Inferred from Electronic Annotation more info
involved_in response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to prostaglandin E	IEA Inferred from Electronic Annotation more info
involved_in response to prostaglandin E	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	IEA Inferred from Electronic Annotation more info
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serotonin N-acetyltransferase

Names: aralkylamine N-acetyltransferase; serotonin acetylase

NP_033721.1

EC 2.3.1.87

XP_030101333.1

EC 2.3.1.87

XP_030101334.1

EC 2.3.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009591.3 → NP_033721.1 serotonin N-acetyltransferase

See identical proteins and their annotated locations for NP_033721.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter and protein-coding transcript.

Source sequence(s)

AL607039, CO040083

Consensus CDS

CCDS25671.1

UniProtKB/Swiss-Prot

O88816

UniProtKB/TrEMBL

Q14A64

Related

ENSMUSP00000122895.2, ENSMUST00000153476.8

Conserved Domains (2) summary

COG0456
Location:31 → 175

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

cl17182
Location:31 → 179

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RNA

NR_033223.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF004110, AL607039, CO040083

Related

ENSMUST00000021160.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

116482547..116489022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245473.2 → XP_030101333.1 serotonin N-acetyltransferase isoform X1

Conserved Domains (1) summary

cl17182
Location:67 → 129

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
XM_030245474.2 → XP_030101334.1 serotonin N-acetyltransferase isoform X2

Conserved Domains (1) summary

pfam00583
Location:81 → 207

Acetyltransf_1; Acetyltransferase (GNAT) family