Kif23 kinesin family member 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif23provided by MGI
Official Full Name: kinesin family member 23provided by MGI
Primary source: MGI:MGI:1919069
See related: Ensembl:ENSMUSG00000032254 AllianceGenome:MGI:1919069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CHO1; Knsl5; MKLP1; MKLP-1; 3110001D19Rik
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including mitotic cytokinesis; mitotic spindle midzone assembly; and positive regulation of cytokinesis. Located in intercellular bridge. Is expressed in several structures, including alimentary system; hindbrain; olfactory epithelium; submandibular gland primordium; and ventricular layer. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type III. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 11.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 33.5 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (61824559..61854078, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (61917277..61946810, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis.
Title: Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis.
Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III.
Title: Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III.
Kif23 up-regulation promotes cell proliferation and gastric cancer progression.
Title: KIF23 Promotes Gastric Cancer by Stimulating Cell Proliferation.
depletion of KIF23 inhibited lung tumor formation in vivo, similar to what is seen with deletion of MMB. In vitro, the depletion of KIF23 in lung cancer cell lines showed strong anti-proliferative activity, which was accompanied by apoptosis in a subset of cell lines.
Title: An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C87313 (e-PCR)
- UniSTS:208390

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in Flemming body	ISO Inferred from Sequence Orthology more info
part_of centralspindlin complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF23

Names: kinesin-like 5 (mitotic kinesin-like protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405055.1 → NP_001391984.1 kinesin-like protein KIF23 isoform 1

Status: VALIDATED

Source sequence(s)

AC151969
NM_001405056.1 → NP_001391985.1 kinesin-like protein KIF23 isoform 3

Status: VALIDATED

Source sequence(s)

AC151969
NM_001405057.1 → NP_001391986.1 kinesin-like protein KIF23 isoform 4

Status: VALIDATED

Source sequence(s)

AC151969
NM_024245.5 → NP_077207.3 kinesin-like protein KIF23 isoform 2

See identical proteins and their annotated locations for NP_077207.3

Status: VALIDATED

Source sequence(s)

AC151969

Consensus CDS

CCDS40662.1

UniProtKB/Swiss-Prot

E9Q5G3, Q80V30, Q99PT8

Related

ENSMUSP00000034815.8, ENSMUST00000034815.9

Conserved Domains (4) summary

cd01368
Location:24 → 434

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:31 → 436

Kinesin; Kinesin motor domain

pfam08702
Location:498 → 603

Fib_alpha; Fibrinogen alpha/beta chain family

pfam16540
Location:797 → 896

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

61824559..61854078 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244618.2 → XP_030100478.1 kinesin-like protein KIF23 isoform X4

Conserved Domains (3) summary

pfam05483
Location:504 → 690

SCP-1; Synaptonemal complex protein 1 (SCP-1)

cd01368
Location:24 → 448

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam16540
Location:707 → 809

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
XM_006511453.5 → XP_006511516.1 kinesin-like protein KIF23 isoform X2

Conserved Domains (3) summary

pfam05483
Location:504 → 690

SCP-1; Synaptonemal complex protein 1 (SCP-1)

cd01368
Location:24 → 448

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam16540
Location:811 → 913

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1