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    Iapp islet amyloid polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 15874, updated on 9-Dec-2024

    Summary

    Official Symbol
    Iappprovided by MGI
    Official Full Name
    islet amyloid polypeptideprovided by MGI
    Primary source
    MGI:MGI:96382
    See related
    Ensembl:ENSMUSG00000041681 AllianceGenome:MGI:96382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAP
    Summary
    Predicted to enable identical protein binding activity; lipid binding activity; and receptor ligand activity. Acts upstream of or within negative regulation of bone resorption; negative regulation of osteoclast differentiation; and sensory perception of pain. Located in extracellular space. Is expressed in embryo; pancreas; pancreas primordium; and pancreas trunk epithelium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 1.6), genital fat pad adult (RPKM 1.5) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Iapp in Genome Data Viewer
    Location:
    6 G2; 6 73.81 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142244151..142249546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142298425..142303820)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene STARR-seq mESC enhancer starr_17700 Neighboring gene predicted gene, 18159 Neighboring gene STARR-seq mESC enhancer starr_17701 Neighboring gene predicted gene, 53313 Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene STARR-seq mESC enhancer starr_17703 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6502 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ protein-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amylin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amylin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP/PKA signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    islet amyloid polypeptide
    Names
    amylin
    diabetes-associated peptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010491.2NP_034621.1  islet amyloid polypeptide precursor

      See identical proteins and their annotated locations for NP_034621.1

      Status: VALIDATED

      Source sequence(s)
      BC027527, CJ042995
      Consensus CDS
      CCDS39694.1
      UniProtKB/Swiss-Prot
      P12968
      Related
      ENSMUSP00000043956.3, ENSMUST00000041993.3
      Conserved Domains (1) summary
      smart00113
      Location:3677
      CALCITONIN; calcitonin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142244151..142249546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)