Zdhhc13 zinc finger, DHHC domain containing 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc13provided by MGI
Official Full Name: zinc finger, DHHC domain containing 13provided by MGI
Primary source: MGI:MGI:1919227
See related: Ensembl:ENSMUSG00000030471 AllianceGenome:MGI:1919227
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: skc4; kojak; HIP3RP; Hip14l; C530010M18; 2410004E01Rik
Summary: Enables magnesium ion transmembrane transporter activity and palmitoyltransferase activity. Predicted to be involved in magnesium ion transmembrane transport. Located in Golgi membrane and Golgi-associated vesicle membrane. Is expressed in several structures, including early conceptus; esophagus epithelium; genitourinary system; molar; and sensory organ. Used to study Huntington's disease. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 21.6), bladder adult (RPKM 15.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 31.11 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (48438751..48477188)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (48788998..48827440)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability.
Title: Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability.
Zdhhc13-dependent Drp1 S-palmitoylation, which acting alone or in concert, enables the normal occurrence of the fission-fusion process.
Title: Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills.
The loss of ZDDHC13 in skin, impairs the multiple barrier functions and leads to a dermatitis lesion in response to microbial encounters.
Title: Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis.
Homozygous Zdhhc13luc/Zdhhc13luc mice developed generalized hypotrichosis, associated with abnormal hair cycle, epidermal and sebaceous gland hyperplasia, hyperkeratosis, and increased epidermal thickness
Title: Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene.
Data show that the ankyrin repeat (AR) domains of S-acyltransferases zDHHC17 and zDHHC13 recognize peptide sequence in several unrelated proteins.
Title: Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.
Zdhhc13 regulates Smad6 during BMP-dependent signaling and early lineage decisions in an in vitro cell model.
Title: Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity.
Loss of Hip14 and Hip14l leads to early embryonic lethality at day embryonic day 10-11 due to failed chorioallantoic fusion.
Title: Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.
Zdhhc13 is a novel regulator of postnatal skeletal development and bone mass acquisition.
Title: Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.
Hip14l-deficient mice develop adult-onset, neuropathological deficits characteristic of Huntington disease.
Title: Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
A second gene trap allele of Zdhhc13 has the same phenotypes, suggesting that this is a loss of function allele.
Title: Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5)
Gene trapped (1)
Spontaneous (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Zdhhc13 (e-PCR), detects polymorphism
- UniSTS:526908

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables magnesium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in magnesium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi-associated vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC13

Names: DHHC-13; HIP14-related protein; huntingtin-interacting protein 14-related protein; probable palmitoyltransferase ZDHHC13; zinc finger DHHC domain-containing protein 13

NP_082307.1

EC 2.3.1.225

XP_006540959.1

EC 2.3.1.225

XP_030098440.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028031.3 → NP_082307.1 palmitoyltransferase ZDHHC13

See identical proteins and their annotated locations for NP_082307.1

Status: PROVISIONAL

Source sequence(s)

AC124977

Consensus CDS

CCDS52259.1

UniProtKB/Swiss-Prot

Q3UK32, Q3UKV1, Q9CWU2

Related

ENSMUSP00000112498.2, ENSMUST00000118927.8

Conserved Domains (5) summary

cd00204
Location:79 → 192

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01529
Location:423 → 556

zf-DHHC; DHHC palmitoyltransferase

pfam12796
Location:86 → 179

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:202 → 257

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:81 → 112

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

48438751..48477188

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242580.2 → XP_030098440.1 palmitoyltransferase ZDHHC13 isoform X1

UniProtKB/TrEMBL

D3YY07

Conserved Domains (4) summary

COG0666
Location:15 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:18 → 49

ANK; ANK repeat [structural motif]

pfam01529
Location:293 → 427

DHHC; DHHC palmitoyltransferase

cl26595
Location:151 → 262

DUF2070; Predicted membrane protein (DUF2070)
XM_006540896.5 → XP_006540959.1 palmitoyltransferase ZDHHC13 isoform X1

See identical proteins and their annotated locations for XP_006540959.1

UniProtKB/TrEMBL

D3YY07

Related

ENSMUSP00000123603.2, ENSMUST00000125280.8

Conserved Domains (4) summary

COG0666
Location:15 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:18 → 49

ANK; ANK repeat [structural motif]

pfam01529
Location:293 → 427

DHHC; DHHC palmitoyltransferase

cl26595
Location:151 → 262

DUF2070; Predicted membrane protein (DUF2070)