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    Sqor Sulfide quinone oxidoreductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sqorprovided by FlyBase
    Official Full Name
    Sulfide quinone oxidoreductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035515
    Locus tag
    Dmel_CG14997
    See related
    AllianceGenome:FB:FBgn0035515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04863; CG14997; Dmel\CG14997
    Summary
    Predicted to enable FAD binding activity; glutathione-dependent sulfide quinone oxidoreductase activity; and sulfide:quinone oxidoreductase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human SQOR (sulfide quinone oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sqor in Genome Data Viewer
    Location:
    64A10-64A10; 3-10 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4240173..4242603)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4240173..4242603)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR32252 Neighboring gene uncharacterized protein Neighboring gene Ecdysone-inducible gene L2 Neighboring gene antisense RNA:CR45738 Neighboring gene pavarotti Neighboring gene archipelago

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Collins RT, et al. Genetics, 2005 May. PMID 15744048, Free PMC Article
    2. Misexpression screen delineates novel genes controlling Drosophila lifespan. Paik D, et al. Mech Ageing Dev, 2012 May. PMID 22366109, Free PMC Article
    3. Drosophila as a diet discovery tool for treating amino acid disorders. Mele S, et al. Trends Endocrinol Metab, 2023 Feb. PMID 36567227
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits. Durham MF, et al. Nat Commun, 2014 Jul 8. PMID 25000897

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione-dependent sulfide quinone oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfide:quinone oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfide oxidation, using sulfide:quinone oxidoreductase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sulfide quinone oxidoreductase
    Names
    CG14997-PA
    CG14997-PB
    Sqor-PA
    Sqor-PB
    NP_647877.1
    NP_728963.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4240173..4242603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168071.1 → NP_728963.1  sulfide quinone oxidoreductase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZF6
      Related
      FBpp0073081, FBtr0073225
      Conserved Domains (1) summary
      pfam07992
      Location:59 → 342
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_139620.2 → NP_647877.1  sulfide quinone oxidoreductase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZF6
      Related
      FBpp0073082
      Conserved Domains (1) summary
      pfam07992
      Location:59 → 342
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZF6 Q9VZF6

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