U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Timp Tissue inhibitor of metalloproteases [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41248, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Timpprovided by FlyBase
    Official Full Name
    Tissue inhibitor of metalloproteasesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025879
    Locus tag
    Dmel_CG6281
    See related
    AllianceGenome:FB:FBgn0025879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6281; Dmel\CG6281; dTIMP; Dtimp; DTIMP; timp; TIMP; TIMP1
    Summary
    Enables metalloendopeptidase inhibitor activity. Involved in several processes, including imaginal disc-derived wing expansion; open tracheal system development; and ventral cord development. Located in dendrite. Is expressed in several structures, including adult head; adult heart; embryonic labial sensory complex; embryonic/larval dorsal vessel; and larval foregut atrium. Human ortholog(s) of this gene implicated in Moyamoya disease; Sorsby's fundus dystrophy; breast carcinoma; nephroblastoma; and urinary bladder cancer. Orthologous to several human genes including TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Timp in Genome Data Viewer
    Location:
    86A1-86A1; 3-49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10203875..10213007, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6029597..6038729, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Bestrophin 1 Neighboring gene uncharacterized protein Neighboring gene Synapsin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Coordinated molecular and ecological adaptations underlie a highly successful parasitoid. Pang L, et al. Elife, 2024 Jun 21. PMID 38904661, Free PMC Article
    2. Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila. Godenschwege TA, et al. Eur J Cell Biol, 2000 Jul. PMID 10961449
    3. Tissue inhibitors of metalloproteinases. Murphy G. Genome Biol, 2011 Nov 11. PMID 22078297, Free PMC Article
    4. Requirement of matrix metalloproteinase-1 for intestinal homeostasis in the adult Drosophila midgut. Lee SH, et al. Exp Cell Res, 2012 Mar 10. PMID 22265916
    5. Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome. Siller SS, et al. Neural Plast, 2012. PMID 22685676, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results demonstrating a crucial role for timp in tissue organization and gamete production thus provide a link between the regulation of ECM metabolism and tissue homeostasis.
      Title: ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary.
    2. identification as endogenous inhibitor of the Drosophila matrix metalloproteinases
      Title: Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in delamination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing expansion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tracheal outgrowth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tracheal pit formation in open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tissue inhibitor of metalloproteases
    Names
    CG6281-PB
    Timp-PB
    tissue inhibitor of metalloproteinases

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10203875..10213007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169336.4 → NP_731461.1  tissue inhibitor of metalloproteases [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731461.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2N5, O96747, Q9VH14
      Related
      FBpp0081722
      Conserved Domains (1) summary
      pfam00965
      Location:26 → 197
      TIMP; Tissue inhibitor of metalloproteinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH14.1 Q9VH14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous