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    SOCS6 suppressor of cytokine signaling 6 [ Gallus gallus (chicken) ]

    Gene ID: 421020, updated on 17-Aug-2024

    Summary

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    Symbol
    SOCS6provided by CGNC
    Full Name
    suppressor of cytokine signaling 6provided by CGNC
    Primary source
    CGNC:10278
    See related
    Ensembl:ENSGALG00010001225
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See SOCS6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (93148584..93176550, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (93232502..93260493, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112531828 Neighboring gene uncharacterized LOC112531829 Neighboring gene microRNA 6584 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene uncharacterized LOC124417735 Neighboring gene rotatin Neighboring gene CD226 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6). Fu M, et al. Virus Res, 2018 Jul 2. PMID 29777734
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gga-miR-454 increased the expression of IFN-beta by targeting SOCS6, enhancing the antiviral response of host cells. These findings highlight a crucial role of gga-miR-454 in host defense against infectious bursal disease virus infection.
      Title: gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127312.1 → NP_001120784.1  suppressor of cytokine signaling 6

      See identical proteins and their annotated locations for NP_001120784.1

      Status: PROVISIONAL

      Source sequence(s)
      EF544593
      UniProtKB/TrEMBL
      B2WUP2
      Related
      ENSGALP00010001386.1, ENSGALT00010002836.1
      Conserved Domains (2) summary
      cd10387
      Location:372 → 471
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:494 → 534
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      93148584..93176550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015282391.4 → XP_015137877.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      B2WUP2
      Related
      ENSGALP00010001385.1, ENSGALT00010002835.1
      Conserved Domains (2) summary
      cd10387
      Location:372 → 471
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:494 → 534
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    2. XM_015282390.4 → XP_015137876.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      B2WUP2
      Related
      ENSGALP00010001391.1, ENSGALT00010002841.1
      Conserved Domains (2) summary
      cd10387
      Location:372 → 471
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:494 → 534
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    3. XM_046924961.1 → XP_046780917.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      B2WUP2
      Related
      ENSGALP00010001383.1, ENSGALT00010002833.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      93232502..93260493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046911486.1 → XP_046767442.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      B2WUP2

    2. XM_046911485.1 → XP_046767441.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      B2WUP2

    3. XM_046911487.1 → XP_046767443.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      B2WUP2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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