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    CDH7 cadherin 7 [ Gallus gallus (chicken) ]

    Gene ID: 374007, updated on 3-Dec-2024

    Summary

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    Symbol
    CDH7provided by CGNC
    Full Name
    cadherin 7provided by CGNC
    Primary source
    CGNC:49001
    See related
    Ensembl:ENSGALG00010001209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    cadherin-7
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    Genomic context

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    See CDH7 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (95080718..95167017, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (95155649..95242238, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene cadherin 19 Neighboring gene uncharacterized LOC121109735 Neighboring gene microRNA 3524b Neighboring gene uncharacterized LOC121109736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadherin-7 mediates proper neural crest cell-placodal neuron interactions during trigeminal ganglion assembly. Wu CY, et al. Genesis, 2019 Jan. PMID 30461190, Free PMC Article
    2. Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning. Kawano R, et al. Open Biol, 2017 Dec. PMID 29263249, Free PMC Article
    3. Identification and characterization of a soluble cadherin-7 isoform produced by alternative splicing. Kawano R, et al. J Biol Chem, 2002 Dec 6. PMID 12364338
    4. Prototypical type I E-cadherin and type II cadherin-7 mediate very distinct adhesiveness through their extracellular domains. Chu YS, et al. J Biol Chem, 2006 Feb 3. PMID 16253998
    5. Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins. Nakagawa S, et al. Development, 1995 May. PMID 7540531

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly.
      Title: Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly.
    2. Cadherin-7 is required for proper neural crest cell-placodal neuron interactions during trigeminal ganglion assembly.
      Title: Cadherin-7 mediates proper neural crest cell-placodal neuron interactions during trigeminal ganglion assembly.
    3. Cdh7 functions as a receptor for Shh and enhances Shh signaling during neural tube patterning.
      Title: Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning.
    4. The endogenous expression of cadherin-7 in developing spinal cord is repressed through overexpression of Pax3 and Pax7.
      Title: Pax3 and Pax7 interact reciprocally and regulate the expression of cadherin-7 through inducing neuron differentiation in the developing chicken spinal cord.
    5. Reduction of the expression of cadherin-7, a cadherin predominantly expressed in motor neurons only during their migration, also perturbs divisional segregation.
      Title: Catenin-dependent cadherin function drives divisional segregation of spinal motor neurons.
    6. Cadherin-7 and cadherin-11 expressed by the migrating neural crest cells can be regulated by the canonical Wnt pathway.
      Title: Regulation of cadherin expression in the chicken neural crest by the Wnt/β-catenin signaling pathway.
    7. Cad7 and Cad6B differentially regulate cranial motoneuron growth, branching and axon guidance.
      Title: Cadherin-7 and cadherin-6B differentially regulate the growth, branching and guidance of cranial motor axons.
    8. Cadherin-7 controls cell migration in chick limb bud mesenchymal cells.
      Title: Alterations in the temporal expression and function of cadherin-7 inhibit cell migration and condensation during chondrogenesis of chick limb mesenchymal cells in vitro.
    9. cadherin-7 was expressed in the robust nucleus of the arcopallium (RA) in the sensory learning stage, and its expression was downregulated during the sensorimotor learning stage. This downregulation of cadherin-7 was sexually dimorphic.
      Title: Expression analysis of cadherins in the songbird brain: relationship to vocal system development.
    10. the extracellular domain exerts by far the dominant effect on cell adhesivity, that of E-cadherin conferring high adhesivity, and that of cadherin-7 conferring low adhesivity
      Title: Prototypical type I E-cadherin and type II cadherin-7 mediate very distinct adhesiveness through their extracellular domains.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-7
    Names
    cadherin 7, type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204187.3 → NP_989518.3  cadherin-7 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000042
      UniProtKB/Swiss-Prot
      Q90763
      UniProtKB/TrEMBL
      F1P1D4
      Related
      ENSGALP00010001346.1, ENSGALT00010002796.1
      Conserved Domains (2) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      95080718..95167017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040674150.2 → XP_040530084.1  cadherin-7 isoform X2

      Conserved Domains (1) summary
      cd11304
      Location:15 → 62
      Cadherin_repeat; Cadherin tandem repeat domain

    2. XM_040674141.2 → XP_040530075.1  cadherin-7 isoform X1

      UniProtKB/TrEMBL
      F1P1D3, Q8AWW2
      Related
      ENSGALP00010001344.1, ENSGALT00010002795.1
      Conserved Domains (2) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      95155649..95242238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910189.1 → XP_046766145.1  cadherin-7 isoform X2

    2. XM_046910188.1 → XP_046766144.1  cadherin-7 isoform X1

      UniProtKB/TrEMBL
      F1P1D3, Q8AWW2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90763.1 GenPept UniProtKB/Swiss-Prot:Q90763

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials