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    MAVS mitochondrial antiviral signaling protein [ Gallus gallus (chicken) ]

    Gene ID: 422936, updated on 3-Dec-2024

    Summary

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    Official Symbol
    MAVSprovided by CGNC
    Official Full Name
    mitochondrial antiviral signaling proteinprovided by CGNC
    Primary source
    CGNC:51863
    See related
    Ensembl:ENSGALG00010016469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    chCARDIF
    Orthologs
    human mouse all
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    Genomic context

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    See MAVS in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (88125587..88133674, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (87928940..87937029, complement)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 24 Neighboring gene microRNA 103a-2 Neighboring gene pantothenate kinase 2 Neighboring gene protein tyrosine phosphatase, receptor type A Neighboring gene mitochondrial ribosomal protein S26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens. Yu D, et al. Gene, 2014 Jul 25. PMID 24835312
    2. Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS. Yu L, et al. BMC Vet Res, 2017 Nov 13. PMID 29132350, Free PMC Article
    3. IRF7 Is Involved in Both STING and MAVS Mediating IFN-β Signaling in IRF3-Lacking Chickens. Cheng Y, et al. J Immunol, 2019 Oct 1. PMID 31366714
    4. Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2. Liniger M, et al. J Virol, 2012 Jan. PMID 22072756, Free PMC Article
    5. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IRF7 Is Involved in Both STING and MAVS Mediating IFN-beta Signaling in IRF3-Lacking Chickens.
      Title: IRF7 Is Involved in Both STING and MAVS Mediating IFN-β Signaling in IRF3-Lacking Chickens.
    2. Infectious bronchitis virus can cleave MAVS
      Title: Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.
    3. a considerably high genetic variability of the MAVS gene, and the 3'-UTR variants had an ability to regulate mRNA expression. These results would cast some clues on understanding the potential role of MAVS on viral resistance in chicken
      Title: Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens.
    4. Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.
      Title: Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    mitochondrial antiviral-signaling protein
    Names
    CARDIF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012893.2 → NP_001012911.2  mitochondrial antiviral-signaling protein

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000077
      UniProtKB/TrEMBL
      A0A8V0YWE2, W0S6J0
      Conserved Domains (2) summary
      PHA03255
      Location:444 → 636
      PHA03255; BDLF3; Provisional
      cd08811
      Location:3 → 93
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      88125587..88133674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046940275.1 → XP_046796231.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0YWE2, W0S6J0

    2. XM_046940277.1 → XP_046796233.1  mitochondrial antiviral-signaling protein isoform X2

      UniProtKB/TrEMBL
      A0A8V0YPL4

    3. XM_046940276.1 → XP_046796232.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0YWE2, W0S6J0
      Related
      ENSGALP00010022935.1, ENSGALT00010039676.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      87928940..87937029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046916446.1 → XP_046772402.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/TrEMBL
      Q5F3P5, W0S6J0

    2. XM_046916448.1 → XP_046772404.1  mitochondrial antiviral-signaling protein isoform X2

      UniProtKB/TrEMBL
      A0A8V0YPL4

    3. XM_046916447.1 → XP_046772403.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/TrEMBL
      Q5F3P5, W0S6J0
    Nucleotide Protein Strain
    Heading Accession and Version

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