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    dgn-2 Peptidase S72 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186365, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgn-2
    Official Full Name
    Peptidase S72 domain-containing protein
    Primary source
    WormBase:WBGene00018943
    Locus tag
    CELE_F56C3.6
    See related
    AllianceGenome:WB:WBGene00018943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable laminin binding activity. Predicted to be involved in axon guidance; morphogenesis of an epithelium; and nerve development. Predicted to be located in membrane. Predicted to be part of dystroglycan complex. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dgn-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (1365474..1367516, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF4129 domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MHC class II antigen K

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans dystroglycan DGN-1 functions in epithelia and neurons, but not muscle, and independently of dystrophin. Johnson RP, et al. Development, 2006 May. PMID 16611689
    2. A new role for laminins as modulators of protein toxicity in Caenorhabditis elegans. Jensen LT, et al. Aging Cell, 2012 Feb. PMID 22051349, Free PMC Article
    3. Basement membranes. Kramer JM. WormBook, 2005 Sep 1. PMID 18050423, Free PMC Article
    4. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. Ziel JW, et al. Nat Cell Biol, 2009 Feb. PMID 19098902, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables laminin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nerve development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of dystroglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dystrophin-associated glycoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase S72 domain-containing protein
    NP_508253.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1365474..1367516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075852.1 → NP_508253.1  Peptidase S72 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61756
      Conserved Domains (1) summary
      pfam05454
      Location:197 → 356
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    Nucleotide Protein
    Heading Accession and Version

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