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    AIFM3 apoptosis inducing factor, mitochondria associated 3 [ Gallus gallus (chicken) ]

    Gene ID: 416999, updated on 3-Dec-2024

    Summary

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    Symbol
    AIFM3provided by CGNC
    Full Name
    apoptosis inducing factor, mitochondria associated 3provided by CGNC
    Primary source
    CGNC:5837
    See related
    Ensembl:ENSGALG00010000431
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See AIFM3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (10043982..10067899)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (10043447..10068779)

    Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon, catalytic subunit Neighboring gene caspase recruitment domain family, member 8 Neighboring gene transmembrane protein 17-like Neighboring gene chromosome 15 open reading frame, human C14orf166B Neighboring gene purinergic receptor P2X 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in execution phase of apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apoptosis-inducing factor 3
    Names
    apoptosis-inducing factor, mitochondrion-associated, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10043982..10067899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046901408.1 → XP_046757364.1  apoptosis-inducing factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0X042, A0A8V0X7N1
      Related
      ENSGALP00010000460.1, ENSGALT00010000894.1

    2. XM_046901409.1 → XP_046757365.1  apoptosis-inducing factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V0X042, A0A8V0X796
      Related
      ENSGALP00010000459.1, ENSGALT00010000893.1
      Conserved Domains (3) summary
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    3. XM_025155546.3 → XP_025011314.2  apoptosis-inducing factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A8V0X2X4
      Conserved Domains (2) summary
      COG0446
      Location:197 → 535
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

    4. XM_025155548.3 → XP_025011316.2  apoptosis-inducing factor 3 isoform X4

      UniProtKB/TrEMBL
      A0A8V0X2X4, A0A8V0X589
      Related
      ENSGALP00010000461.1, ENSGALT00010000895.1
      Conserved Domains (2) summary
      COG0446
      Location:197 → 535
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

    5. XM_415290.8 → XP_415290.4  apoptosis-inducing factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V0X042, A0A8V0X796
      Related
      ENSGALP00010000462.1, ENSGALT00010000896.1
      Conserved Domains (3) summary
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    6. XM_046901410.1 → XP_046757366.1  apoptosis-inducing factor 3 isoform X5

      UniProtKB/TrEMBL
      A0A8V0X585
      Related
      ENSGALP00010000455.1, ENSGALT00010000889.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10043447..10068779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046928502.1 → XP_046784458.1  apoptosis-inducing factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V0X042, A0A8V0X796
      Conserved Domains (3) summary
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    2. XM_040685086.2 → XP_040541020.1  apoptosis-inducing factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A8V0X2X4
      Conserved Domains (2) summary
      COG0446
      Location:197 → 535
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

    3. XM_040685089.2 → XP_040541023.1  apoptosis-inducing factor 3 isoform X4

      UniProtKB/TrEMBL
      A0A8V0X2X4, A0A8V0X589
      Conserved Domains (2) summary
      COG0446
      Location:197 → 535
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

    4. XM_040685091.2 → XP_040541025.1  apoptosis-inducing factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V0X042, A0A8V0X796
      Conserved Domains (3) summary
      cd03478
      Location:70 → 164
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    5. XM_046928503.1 → XP_046784459.1  apoptosis-inducing factor 3 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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