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    TIAM2 T-cell lymphoma invasion and metastasis 2 [ Gallus gallus (chicken) ]

    Gene ID: 421648, updated on 17-Aug-2024

    Summary

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    Symbol
    TIAM2provided by CGNC
    Full Name
    T-cell lymphoma invasion and metastasis 2provided by CGNC
    Primary source
    CGNC:66407
    See related
    Ensembl:ENSGALG00010005307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TIAM2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (50104602..50272752)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (50010186..50178352)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene CNKSR family member 3 Neighboring gene SR-related CTD associated factor 8 Neighboring gene uncharacterized LOC121110260 Neighboring gene transcription factor B1, mitochondrial Neighboring gene claudin 20 Neighboring gene NADPH oxidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor TIAM2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267535.1 → NP_001254464.1  rho guanine nucleotide exchange factor TIAM2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000063
      UniProtKB/TrEMBL
      A0A1D5PML9
      Related
      ENSGALP00010007145.1, ENSGALT00010012581.1
      Conserved Domains (6) summary
      cd00992
      Location:891 → 974
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:505 → 631
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1297 → 1469
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam00169
      Location:507 → 620
      PH; PH domain
      pfam00621
      Location:1106 → 1295
      RhoGEF; RhoGEF domain
      cl00155
      Location:812 → 889
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      50104602..50272752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046938839.1 → XP_046794795.1  rho guanine nucleotide exchange factor TIAM2 isoform X1

    2. XM_046938838.1 → XP_046794794.1  rho guanine nucleotide exchange factor TIAM2 isoform X1

    3. XM_025148727.3 → XP_025004495.1  rho guanine nucleotide exchange factor TIAM2 isoform X2

      Conserved Domains (5) summary
      smart00325
      Location:1125 → 1314
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:910 → 993
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:505 → 631
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1316 → 1488
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      cl00155
      Location:833 → 908
      UBQ; Ubiquitin-like proteins

    4. XM_015284073.4 → XP_015139559.1  rho guanine nucleotide exchange factor TIAM2 isoform X1

      Conserved Domains (6) summary
      cd00992
      Location:911 → 994
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:505 → 631
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1317 → 1489
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam00169
      Location:507 → 620
      PH; PH domain
      pfam00621
      Location:1126 → 1315
      RhoGEF; RhoGEF domain
      cl00155
      Location:834 → 909
      UBQ; Ubiquitin-like proteins

    5. XM_046938841.1 → XP_046794797.1  rho guanine nucleotide exchange factor TIAM2 isoform X4

    6. XM_046938840.1 → XP_046794796.1  rho guanine nucleotide exchange factor TIAM2 isoform X3

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      50010186..50178352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913924.1 → XP_046769880.1  rho guanine nucleotide exchange factor TIAM2 isoform X1

    2. XM_046913923.1 → XP_046769879.1  rho guanine nucleotide exchange factor TIAM2 isoform X1

    3. XM_046913926.1 → XP_046769882.1  rho guanine nucleotide exchange factor TIAM2 isoform X2

    4. XM_046913925.1 → XP_046769881.1  rho guanine nucleotide exchange factor TIAM2 isoform X1

    5. XM_046913928.1 → XP_046769884.1  rho guanine nucleotide exchange factor TIAM2 isoform X4

    6. XM_046913927.1 → XP_046769883.1  rho guanine nucleotide exchange factor TIAM2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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