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    HNF4A hepatocyte nuclear factor 4 alpha [ Gallus gallus (chicken) ]

    Gene ID: 419198, updated on 3-Dec-2024

    Summary

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    Symbol
    HNF4Aprovided by CGNC
    Full Name
    hepatocyte nuclear factor 4 alphaprovided by CGNC
    Primary source
    CGNC:50941
    See related
    Ensembl:ENSGALG00010024342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    HNF4alpha
    Orthologs
    human mouse all
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    Genomic context

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    See HNF4A in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (5759568..5789213, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (5554204..5583846, complement)

    Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene serine incorporator 3 Neighboring gene alpha tocopherol transfer protein like Neighboring gene uncharacterized LOC121107328 Neighboring gene uncharacterized LOC107054880 Neighboring gene R3H domain containing like Neighboring gene uncharacterized LOC107057318

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α. Yang Q, et al. FEBS J, 2014 Mar. PMID 24418194
    2. Immunohistochemical detection of hepatocyte nuclear factor-4α in vertebrates. Jiang S, et al. Microsc Res Tech, 2021 Dec. PMID 34196449
    3. Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Handschin C, et al. Arch Biochem Biophys, 2005 Feb 1. PMID 15629111
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immunohistochemical detection of hepatocyte nuclear factor-4alpha in vertebrates.
      Title: Immunohistochemical detection of hepatocyte nuclear factor-4α in vertebrates.
    2. The results of overexpressing C/EBPalpha and HNF4alpha in cultured cells confirmed that both C/EBPalpha and HNF4alpha contribute significantly to sustaining a high level of CYP2D49 transcription.
      Title: Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 4-alpha
    Names
    hepatic nuclear factor 4alpha
    nuclear receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030855.2 → NP_001026026.2  hepatocyte nuclear factor 4-alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000328
      UniProtKB/TrEMBL
      Q5ILH0
      Related
      ENSGALP00010036240.1, ENSGALT00010059366.1

    2. NM_001396805.1 → NP_001383734.1  hepatocyte nuclear factor 4-alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000328
      UniProtKB/TrEMBL
      Q5ILH0
      Conserved Domains (2) summary
      cd06931
      Location:152 → 374
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:61 → 136
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    3. NM_001396806.1 → NP_001383735.1  hepatocyte nuclear factor 4-alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000328
      UniProtKB/TrEMBL
      Q5ILH0
      Conserved Domains (2) summary
      cd06931
      Location:129 → 351
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:38 → 113
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      5759568..5789213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025142195.3 → XP_024997963.1  hepatocyte nuclear factor 4-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V1A4M5, Q5ILH0
      Related
      ENSGALP00010036242.1, ENSGALT00010059368.1
      Conserved Domains (2) summary
      cd06931
      Location:130 → 352
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:39 → 114
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      5554204..5583846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046930674.1 → XP_046786630.1  hepatocyte nuclear factor 4-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V1A4M5, Q5ILH0
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials