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    GRIA4 glutamate ionotropic receptor AMPA type subunit 4 [ Gallus gallus (chicken) ]

    Gene ID: 396137, updated on 3-Dec-2024

    Summary

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    Symbol
    GRIA4provided by CGNC
    Full Name
    glutamate ionotropic receptor AMPA type subunit 4provided by CGNC
    Primary source
    CGNC:12904
    See related
    Ensembl:ENSGALG00010005223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    GluR4; GluR4c; GluR4d; GluR4s; GLUR4/D
    Orthologs
    human mouse all
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    Genomic context

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    See GRIA4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (181042511..181265072, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (181090985..181312494, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene kelch repeat and BTB domain containing 3 Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene uncharacterized LOC124417379 Neighboring gene uncharacterized LOC121109133 Neighboring gene uncharacterized LOC121113375

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: effect on GluR4 phosphorylation and surface expression. Gomes AR, et al. J Neurochem, 2004 Aug. PMID 15255946
    2. New isoforms of the chick glutamate receptor subunit GluR4: molecular cloning, regional expression and developmental analysis. Ravindranathan A, et al. Brain Res Mol Brain Res, 1997 Oct 15. PMID 9406929
    3. PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression. Gomes AR, et al. Traffic, 2007 Mar. PMID 17233759
    4. Flip and flop isoforms of chick brain AMPA receptor subunits: cloning and analysis of expression patterns. Ravindranathan A, et al. Neuroreport, 1996 Nov 4. PMID 8981452
    5. A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. Aruscavage PJ, et al. RNA, 2000 Feb. PMID 10688364, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4.
      Title: PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression.
    2. Our data show that GluR4 phosphorylation at Ser842 by PKA, and its recruitment to the plasma membrane upon phosphorylation, is regulated by metabotropic receptors
      Title: Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: effect on GluR4 phosphorylation and surface expression.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor 4
    Names
    AMPA receptor GluR4/D
    glutamate receptor subunit GluR4
    glutamate receptor, ionotrophic, AMPA 4
    glutamate receptor, ionotropic, AMPA 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113186.2 → NP_001106657.2  glutamate receptor 4 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg765Gly.
      Source sequence(s)
      JAENSK010000027
      UniProtKB/TrEMBL
      Q90730, Q90858
      Related
      ENSGALP00010006929.1, ENSGALT00010012365.1
      Conserved Domains (2) summary
      cd13715
      Location:414 → 795
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:28 → 400
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    2. NM_205214.3 → NP_990545.2  glutamate receptor 4 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences compared to isoform 1. RNA editing (AGA->GGA) changes Arg765Gly.
      Source sequence(s)
      JAENSK010000027
      UniProtKB/TrEMBL
      A0A1D5PJ69, Q90730, Q90858
      Related
      ENSGALP00010006925.1, ENSGALT00010012361.1
      Conserved Domains (2) summary
      cd13715
      Location:414 → 795
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:28 → 400
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      181042511..181265072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040661315.2 → XP_040517249.1  glutamate receptor 4 isoform X10

      UniProtKB/TrEMBL
      A0A8V0XQ06
      Conserved Domains (2) summary
      cd13715
      Location:461 → 811
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    2. XM_040660594.2 → XP_040516528.1  glutamate receptor 4 isoform X2

      UniProtKB/TrEMBL
      Q90730, Q90858
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    3. XM_040660512.2 → XP_040516446.1  glutamate receptor 4 isoform X1

      UniProtKB/TrEMBL
      Q90730, Q90858
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    4. XM_040661000.2 → XP_040516934.1  glutamate receptor 4 isoform X6

      UniProtKB/TrEMBL
      A0A8V0XJR1
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    5. XM_040660891.2 → XP_040516825.1  glutamate receptor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XJR1
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    6. XM_040660819.2 → XP_040516753.1  glutamate receptor 4 isoform X5

      UniProtKB/TrEMBL
      A0A8V0XJR1
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    7. XM_040660761.2 → XP_040516695.1  glutamate receptor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XJR1
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    8. XM_040661138.2 → XP_040517072.1  glutamate receptor 4 isoform X8

      UniProtKB/TrEMBL
      A0A8V0XJR1, A0A8V0XPZ6
      Related
      ENSGALP00010006927.1, ENSGALT00010012363.1
      Conserved Domains (2) summary
      cd13715
      Location:414 → 795
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:28 → 400
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    9. XM_040661078.2 → XP_040517012.1  glutamate receptor 4 isoform X7

      UniProtKB/TrEMBL
      A0A8V0XJR1
      Related
      ENSGALP00010006933.1, ENSGALT00010012369.1
      Conserved Domains (2) summary
      cd13715
      Location:414 → 795
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:28 → 400
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    10. XM_040660668.2 → XP_040516602.1  glutamate receptor 4 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XJR1
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    11. XM_040660948.2 → XP_040516882.1  glutamate receptor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XJR1
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    12. XM_040661232.2 → XP_040517166.1  glutamate receptor 4 isoform X9

      UniProtKB/TrEMBL
      A0A8V0XQ06
      Conserved Domains (2) summary
      cd13715
      Location:461 → 842
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06388
      Location:78 → 447
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    13. XM_015277725.4 → XP_015133211.1  glutamate receptor 4 isoform X11

      UniProtKB/TrEMBL
      A0A1D5PKY5
      Conserved Domains (1) summary
      cd06388
      Location:28 → 398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor

    RNA

    1. XR_005845305.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      181090985..181312494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906803.1 → XP_046762759.1  glutamate receptor 4 isoform X10

      UniProtKB/TrEMBL
      A0A8V0XQ06

    2. XM_046906792.1 → XP_046762748.1  glutamate receptor 4 isoform X2

      UniProtKB/TrEMBL
      Q90730, Q90858

    3. XM_046906791.1 → XP_046762747.1  glutamate receptor 4 isoform X1

      UniProtKB/TrEMBL
      Q90730, Q90858

    4. XM_046906799.1 → XP_046762755.1  glutamate receptor 4 isoform X6

      UniProtKB/TrEMBL
      A0A8V0XJR1

    5. XM_046906796.1 → XP_046762752.1  glutamate receptor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XJR1

    6. XM_046906795.1 → XP_046762751.1  glutamate receptor 4 isoform X5

      UniProtKB/TrEMBL
      A0A8V0XJR1

    7. XM_046906794.1 → XP_046762750.1  glutamate receptor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XJR1

    8. XM_046906801.1 → XP_046762757.1  glutamate receptor 4 isoform X8

      UniProtKB/TrEMBL
      A0A8V0XJR1, A0A8V0XPZ6

    9. XM_046906800.1 → XP_046762756.1  glutamate receptor 4 isoform X7

      UniProtKB/TrEMBL
      A0A8V0XJR1

    10. XM_046906793.1 → XP_046762749.1  glutamate receptor 4 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XJR1

    11. XM_046906797.1 → XP_046762753.1  glutamate receptor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XJR1

    12. XM_046906802.1 → XP_046762758.1  glutamate receptor 4 isoform X9

      UniProtKB/TrEMBL
      A0A8V0XQ06

    13. XM_046906804.1 → XP_046762760.1  glutamate receptor 4 isoform X11

    RNA

    1. XR_006932646.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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