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    cest-2.2 Carboxylesterase type B domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cest-2.2
    Official Full Name
    Carboxylesterase type B domain-containing protein
    Primary source
    WormBase:WBGene00013874
    Locus tag
    CELE_ZC376.2
    See related
    AllianceGenome:WB:WBGene00013874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cest-2.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (14171639..14175355, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ONECUT (homeobox) Associated Motif containing Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Homeobox domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Photoaffinity probes for nematode pheromone receptor identification. Zhang YK, et al. Org Biomol Chem, 2019 Dec 18. PMID 31781713, Free PMC Article
    2. Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids. Möller S, et al. Aging (Albany NY), 2020 Jul 7. PMID 32634117, Free PMC Article
    3. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Carboxylesterase type B domain-containing protein
    NP_001256566.1
    • Confirmed by transcript evidence
    NP_001256567.1
    • Confirmed by transcript evidence
    NP_001256568.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14171639..14175355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269637.2 → NP_001256566.1  Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23273
      Conserved Domains (1) summary
      cl21494
      Location:18 → 532
      Abhydrolase; alpha/beta hydrolases

    2. NM_001269638.3 → NP_001256567.1  Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Y9
      Conserved Domains (1) summary
      cl21494
      Location:25 → 534
      Abhydrolase; alpha/beta hydrolases

    3. NM_001269639.4 → NP_001256568.1  Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Y8
      Conserved Domains (1) summary
      cl21494
      Location:18 → 185
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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