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    ALKBH2 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase [ Gallus gallus (chicken) ]

    Gene ID: 416897, updated on 17-Aug-2024

    Summary

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    Symbol
    ALKBH2provided by CGNC
    Full Name
    alkB homolog 2, alpha-ketoglutarate dependent dioxygenaseprovided by CGNC
    Primary source
    CGNC:3709
    See related
    Ensembl:ENSGALG00010021476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ALKBH2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (6653853..6665580, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (6664410..6676162, complement)

    Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene D-amino acid oxidase Neighboring gene SV2 related protein Neighboring gene ubiquitin specific peptidase 30 Neighboring gene microRNA 6648-1 Neighboring gene uracil DNA glycosylase Neighboring gene acetyl-CoA carboxylase beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article
    2. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA oxidative demethylase ALKBH2
    Names
    alkB, alkylation repair homolog 2
    NP_001264425.1
    NP_001264426.2
    NP_001264428.1
    NP_001264430.1
    XP_040503956.1
    XP_046784110.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277496.2 → NP_001264425.1  DNA oxidative demethylase ALKBH2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses and alternate 3' structure. This results in shorter 3' coding region and distinct 3' UTR. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      JAENSK010000260
      UniProtKB/TrEMBL
      A0A1D5P2S2
      Conserved Domains (1) summary
      cl21496
      Location:51 → 233
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. NM_001277497.2 → NP_001264426.2  DNA oxidative demethylase ALKBH2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAENSK010000260
      UniProtKB/TrEMBL
      A0A8V0ZID8
      Related
      ENSGALP00010031090.1, ENSGALT00010052078.1
      Conserved Domains (1) summary
      cl21496
      Location:35 → 230
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    3. NM_001277499.2 → NP_001264428.1  DNA oxidative demethylase ALKBH2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences compared to variant 1. These differences result in a distinct 3' UTR and a frameshift in the 3' coding region. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000260
      UniProtKB/TrEMBL
      A0A8V0ZJW6
      Related
      ENSGALP00010031077.1, ENSGALT00010052062.1

    4. NM_001277501.2 → NP_001264430.1  DNA oxidative demethylase ALKBH2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 1. These differences result in a distinct 3' UTR and a frameshift in the 3' coding region. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000260
      UniProtKB/TrEMBL
      A0A8V0ZJX1

    RNA

    1. NR_173335.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000260

    2. NR_173336.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000260

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      6653853..6665580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040648022.2 → XP_040503956.1  DNA oxidative demethylase ALKBH2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZID8
      Conserved Domains (1) summary
      cl21496
      Location:35 → 230
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      6664410..6676162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046928154.1 → XP_046784110.1  DNA oxidative demethylase ALKBH2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001277500.1: Suppressed sequence

      Description
      NM_001277500.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials