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    HEY1 hes related family bHLH transcription factor with YRPW motif 1 [ Gallus gallus (chicken) ]

    Gene ID: 428365, updated on 17-Aug-2024

    Summary

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    Symbol
    HEY1provided by CGNC
    Full Name
    hes related family bHLH transcription factor with YRPW motif 1provided by CGNC
    Primary source
    CGNC:11739
    See related
    Ensembl:ENSGALG00010003330
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See HEY1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (120346174..120350024, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (120536871..120540699, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene SUN domain-containing protein 3-like Neighboring gene stathmin 2 Neighboring gene tumor protein D52 Neighboring gene uncharacterized LOC101750761 Neighboring gene zinc finger and BTB domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth. Ménard M, et al. PLoS Biol, 2018 May. PMID 29750782, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TrkC tumor suppressor activity requires Hey1 and p53.
      Title: Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in circulatory system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hairy/enhancer-of-split related with YRPW motif protein 1
    Names
    hairy/enhancer-of-split related with YRPW motif 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      120346174..120350024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015282862.4 → XP_015138348.2  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XIX5
      Related
      ENSGALP00010004677.1, ENSGALT00010007789.1
      Conserved Domains (2) summary
      smart00511
      Location:160 → 206
      ORANGE; Orange domain
      cl00081
      Location:81 → 162
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    2. XM_025148013.3 → XP_025003781.2  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XIX5
      Conserved Domains (2) summary
      smart00511
      Location:185 → 231
      ORANGE; Orange domain
      cl00081
      Location:81 → 187
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      120536871..120540699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040665052.2 → XP_040520986.1  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XIX5
      Conserved Domains (2) summary
      smart00511
      Location:160 → 206
      ORANGE; Orange domain
      cl00081
      Location:81 → 162
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    2. XM_040665051.2 → XP_040520985.1  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XIX5
      Conserved Domains (2) summary
      smart00511
      Location:185 → 231
      ORANGE; Orange domain
      cl00081
      Location:81 → 187
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials