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    RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 [ Gallus gallus (chicken) ]

    Gene ID: 423327, updated on 3-Dec-2024

    Summary

    Symbol
    RALGAPA1provided by CGNC
    Full Name
    Ral GTPase activating protein catalytic alpha subunit 1provided by CGNC
    Primary source
    CGNC:7666
    See related
    Ensembl:ENSGALG00010006052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    GARNL1
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RALGAPA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (35742066..35854741, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (35712530..35825148, complement)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor alpha Neighboring gene INSM transcriptional repressor 2 Neighboring gene breast cancer metastasis-suppressor 1-like Neighboring gene uncharacterized LOC124418004 Neighboring gene uncharacterized LOC121111054

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    ral GTPase-activating protein subunit alpha-1
    Names
    GTPase activating Rap/RanGAP domain-like 1
    GTPase-activating Rap/RanGAP domain-like 1 protein
    Ral GTPase activating protein, alpha subunit 1 (catalytic)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277447.3NP_001264376.1  ral GTPase-activating protein subunit alpha-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      G0ZS69
      Related
      ENSGALP00010008529.1, ENSGALT00010014512.1
      Conserved Domains (1) summary
      pfam02145
      Location:19392115
      Rap_GAP; Rap/ran-GAP
    2. NM_001277451.3NP_001264380.1  ral GTPase-activating protein subunit alpha-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon in the central region and a 3 nt exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment and an internal aa Val, compared to isoform 1.
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XP96
      Related
      ENSGALP00010008515.1, ENSGALT00010014498.1
      Conserved Domains (1) summary
      pfam02145
      Location:18722048
      Rap_GAP; Rap/ran-GAP
    3. NM_001277452.3NP_001264381.1  ral GTPase-activating protein subunit alpha-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame coding exons in the central region and a 3 nt exon in the 3' coding region, compared to variant 1. The resulting isoform (3) lacks two internal segments and an internal aa Val, compared to isoform 1.
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      G0ZS66
      Conserved Domains (1) summary
      pfam02145
      Location:18252001
      Rap_GAP; Rap/ran-GAP
    4. NM_001277453.3NP_001264382.1  ral GTPase-activating protein subunit alpha-1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two in-frame coding exons in the central region, and lacks a 3 nt exon but has an alternate exon in the 3' region, compared to variant 1. The resulting isoform (4) lacks two internal segments and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      G0ZS65
      Conserved Domains (1) summary
      pfam02145
      Location:18252001
      Rap_GAP; Rap/ran-GAP
    5. NM_001277454.3NP_001264383.1  ral GTPase-activating protein subunit alpha-1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three in-frame coding exons in the central region, but has an additional exon in the 3' region, compared to variant 1. The resulting isoform (5) lacks three internal segments and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      G0ZS68
      Conserved Domains (1) summary
      pfam02145
      Location:17741950
      Rap_GAP; Rap/ran-GAP

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      35742066..35854741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015287381.4XP_015142867.2  ral GTPase-activating protein subunit alpha-1 isoform X13

      UniProtKB/TrEMBL
      G0ZS65
    2. XM_015287379.4XP_015142865.2  ral GTPase-activating protein subunit alpha-1 isoform X11

      UniProtKB/TrEMBL
      G0ZS65
    3. XM_025150742.3XP_025006510.2  ral GTPase-activating protein subunit alpha-1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0XRJ0
    4. XM_015287373.4XP_015142859.2  ral GTPase-activating protein subunit alpha-1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0XRJ0
      Related
      ENSGALP00010008560.1, ENSGALT00010014543.1
    5. XM_015287380.4XP_015142866.2  ral GTPase-activating protein subunit alpha-1 isoform X12

      UniProtKB/TrEMBL
      A0A8V0XP86, G0ZS65
      Related
      ENSGALP00010008510.1, ENSGALT00010014493.1
    6. XM_015287378.4XP_015142864.2  ral GTPase-activating protein subunit alpha-1 isoform X10

      UniProtKB/TrEMBL
      G0ZS69
    7. XM_015287375.4XP_015142861.2  ral GTPase-activating protein subunit alpha-1 isoform X6

      UniProtKB/TrEMBL
      A0A8V0XU76
    8. XM_015287372.4XP_015142858.2  ral GTPase-activating protein subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XU56
      Related
      ENSGALP00010008524.1, ENSGALT00010014507.1
    9. XM_025150740.3XP_025006508.2  ral GTPase-activating protein subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XU76
    10. XM_015287370.4XP_015142856.2  ral GTPase-activating protein subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XU76
    11. XM_015287371.4XP_015142857.2  ral GTPase-activating protein subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XU56
    12. XM_040700991.2XP_040556925.1  ral GTPase-activating protein subunit alpha-1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0XU76
    13. XM_040700993.2XP_040556927.1  ral GTPase-activating protein subunit alpha-1 isoform X9

      UniProtKB/TrEMBL
      A0A8V0XU76

    RNA

    1. XR_005860044.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      35712530..35825148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046918554.1XP_046774510.1  ral GTPase-activating protein subunit alpha-1 isoform X13

      UniProtKB/TrEMBL
      G0ZS65
    2. XM_046918551.1XP_046774507.1  ral GTPase-activating protein subunit alpha-1 isoform X11

      UniProtKB/TrEMBL
      G0ZS65
    3. XM_046918548.1XP_046774504.1  ral GTPase-activating protein subunit alpha-1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0XRJ0
    4. XM_046918545.1XP_046774501.1  ral GTPase-activating protein subunit alpha-1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0XRJ0
    5. XM_046918552.1XP_046774508.1  ral GTPase-activating protein subunit alpha-1 isoform X12

      UniProtKB/TrEMBL
      G0ZS65
    6. XM_046918550.1XP_046774506.1  ral GTPase-activating protein subunit alpha-1 isoform X10

      UniProtKB/TrEMBL
      G0ZS69
    7. XM_046918546.1XP_046774502.1  ral GTPase-activating protein subunit alpha-1 isoform X6

      UniProtKB/TrEMBL
      A0A8V0XU76
    8. XM_046918543.1XP_046774499.1  ral GTPase-activating protein subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XU56
    9. XM_046918544.1XP_046774500.1  ral GTPase-activating protein subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XU76
    10. XM_046918541.1XP_046774497.1  ral GTPase-activating protein subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XU76
    11. XM_046918542.1XP_046774498.1  ral GTPase-activating protein subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XU56
    12. XM_046918547.1XP_046774503.1  ral GTPase-activating protein subunit alpha-1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0XU76
    13. XM_046918549.1XP_046774505.1  ral GTPase-activating protein subunit alpha-1 isoform X9

      UniProtKB/TrEMBL
      A0A8V0XU76

    RNA

    1. XR_006934704.1 RNA Sequence