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    larp-1 La-related protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175680, updated on 9-Dec-2024

    Summary

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    Official Symbol
    larp-1
    Official Full Name
    La-related protein 1
    Primary source
    WormBase:WBGene00020097
    Locus tag
    CELE_R144.7
    See related
    AllianceGenome:WB:WBGene00020097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables poly(G) binding activity and poly(U) RNA binding activity. Predicted to be involved in positive regulation of translation. Located in P-body. Is expressed in several structures, including enteric muscle; excretory cell; intestine; pharynx; and reproductive system. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator) and LARP1B (La ribonucleoprotein 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See larp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (5008925..5017650, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene DUF5683 domain-containing protein Neighboring gene ncRNA Neighboring gene WH2 domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants. Hemphill C, et al. PLoS Genet, 2022 May. PMID 35622856, Free PMC Article
    2. LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline. Zanin E, et al. J Cell Sci, 2010 Aug 15. PMID 20663921
    3. C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. Nykamp K, et al. RNA, 2008 Jul. PMID 18515547, Free PMC Article
    4. Identification and analysis of internal promoters in Caenorhabditis elegans operons. Huang P, et al. Genome Res, 2007 Oct. PMID 17712020, Free PMC Article
    5. Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation. Itani OA, et al. Curr Biol, 2021 Jan 11. PMID 33157031, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data indicate that LARP-1 and NOS-3 promote oogenesis by regulating fem-3 expression through distinct mechanisms.
      Title: LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.
    2. larp-1 null mutants have an oogenesis defect reminiscent of hyperactive Ras-MAPK signaling; LARP-1 protein colocalizes with P bodies, which function in RNA degradation.
      Title: C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(G) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    La-related protein 1
    NP_001040867.2
    • Confirmed by transcript evidence
    NP_001040868.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5008925..5017650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047403.5 → NP_001040868.3  La-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040868.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5MCN2, H2KZ23
      Conserved Domains (2) summary
      smart00684
      Location:1042 → 1080
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08034
      Location:580 → 654
      LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2

    2. NM_001047402.3 → NP_001040867.2  La-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040867.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5MCN2
      Conserved Domains (2) summary
      smart00684
      Location:710 → 748
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cl02755
      Location:307 → 381
      LAM; LA motif RNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5MCN2.2

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