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    TIAM1 T-cell lymphoma invasion and metastasis 1 [ Gallus gallus (chicken) ]

    Gene ID: 418491, updated on 3-Dec-2024

    Summary

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    Symbol
    TIAM1provided by CGNC
    Full Name
    T-cell lymphoma invasion and metastasis 1provided by CGNC
    Primary source
    CGNC:11819
    See related
    Ensembl:ENSGALG00010011699
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TIAM1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (104555472..104730673, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (104644962..104819976, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene claudin-8 Neighboring gene claudin 8 Neighboring gene uncharacterized LOC121106689 Neighboring gene superoxide dismutase 1, soluble

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-lymphoma invasion and metastasis-inducing protein 1; rho guanine nucleotide exchange factor TIAM1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      104555472..104730673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015299682.3 → XP_015155168.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    2. XM_046900829.1 → XP_046756785.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4

    3. XM_015299661.3 → XP_015155147.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    4. XM_015299665.3 → XP_015155151.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    5. XM_046900819.1 → XP_046756775.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4

    6. XM_046900822.1 → XP_046756778.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4

    7. XM_004938381.5 → XP_004938438.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y5Z4, A0A8V0YJ47
      Related
      ENSGALP00010016065.1, ENSGALT00010028009.1
      Conserved Domains (6) summary
      smart00325
      Location:1058 → 1247
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:857 → 939
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:446 → 572
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1249 → 1420
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:780 → 849
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:586 → 683
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    8. XM_015299674.4 → XP_015155160.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    9. XM_046900799.1 → XP_046756755.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y5Z4

    10. XM_040646861.2 → XP_040502795.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Related
      ENSGALP00010016060.1, ENSGALT00010028001.1
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    11. XM_040646871.2 → XP_040502805.1  rho guanine nucleotide exchange factor TIAM1 isoform X7

      Conserved Domains (2) summary
      smart00325
      Location:33 → 222
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:224 → 395
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    12. XM_025144995.3 → XP_025000763.1  rho guanine nucleotide exchange factor TIAM1 isoform X6

      Conserved Domains (2) summary
      smart00325
      Location:55 → 244
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:246 → 417
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    13. XM_046900833.1 → XP_046756789.1  rho guanine nucleotide exchange factor TIAM1 isoform X5

    14. XM_025144990.3 → XP_025000758.1  rho guanine nucleotide exchange factor TIAM1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YED9
      Related
      ENSGALP00010016056.1, ENSGALT00010027989.1
      Conserved Domains (2) summary
      smart00325
      Location:76 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:267 → 438
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      104644962..104819976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040658265.2 → XP_040514199.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    2. XM_046908987.1 → XP_046764943.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4

    3. XM_040658262.2 → XP_040514196.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    4. XM_040658263.2 → XP_040514197.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    5. XM_046908985.1 → XP_046764941.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4

    6. XM_046908986.1 → XP_046764942.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4

    7. XM_040658261.2 → XP_040514195.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y5Z4, A0A8V0YJ47
      Conserved Domains (6) summary
      smart00325
      Location:1058 → 1247
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:857 → 939
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:446 → 572
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1249 → 1420
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:780 → 849
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:586 → 683
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    8. XM_040658264.2 → XP_040514198.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    9. XM_040658266.2 → XP_040514200.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5P0C4, A0A8V0Y5Z4
      Conserved Domains (6) summary
      smart00325
      Location:1046 → 1235
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:845 → 927
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:434 → 560
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1237 → 1408
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:768 → 837
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:574 → 671
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    Nucleotide Protein Strain
    Heading Accession and Version

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