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    NF2 neurofibromin 2 [ Gallus gallus (chicken) ]

    Gene ID: 395158, updated on 3-Dec-2024

    Summary

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    Official Symbol
    NF2provided by CGNC
    Official Full Name
    neurofibromin 2provided by CGNC
    Primary source
    CGNC:6112
    See related
    Ensembl:ENSGALG00010000153
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    cNf2
    Orthologs
    human mouse all
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    Genomic context

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    See NF2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (11064481..11105683, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (11076462..11117700, complement)

    Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene zinc finger matrin-type 5 Neighboring gene calcium binding protein 7 Neighboring gene uncharacterized LOC112533491 Neighboring gene pleckstrin homology domain-containing family A member 4-like Neighboring gene nipsnap homolog 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration. Chen Y, et al. Dev Dyn, 2004 Mar. PMID 14991710
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. c-merlin is developmentally regulated in migrating and differentiating myogenic cells
      Title: Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of gliogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of organelle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    merlin
    Names
    neurofibromatosis 2
    neurofibromin 2 (bilateral acoustic neuroma)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204497.2 → NP_989828.2  merlin

      See identical proteins and their annotated locations for NP_989828.2

      Status: PROVISIONAL

      Source sequence(s)
      AJ720524
      UniProtKB/TrEMBL
      F1P1K6, Q5ZJB0, Q6RW63
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 369
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 595
      ERM; Ezrin/radixin/moesin family

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      11064481..11105683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294835.3 → XP_015150321.1  merlin isoform X1

      UniProtKB/TrEMBL
      A0A8V0WZJ7, Q6RW63
      Related
      ENSGALP00010000157.1, ENSGALT00010000289.1
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 369
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 594
      ERM; Ezrin/radixin/moesin family

    2. XM_046901084.1 → XP_046757040.1  merlin isoform X3

      UniProtKB/TrEMBL
      Q6RW63

    3. XM_015294836.4 → XP_015150322.1  merlin isoform X2

      UniProtKB/TrEMBL
      Q6RW63
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 369
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 579
      ERM; Ezrin/radixin/moesin family

    4. XM_015294837.4 → XP_015150323.1  merlin isoform X2

      UniProtKB/TrEMBL
      Q6RW63
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 369
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 579
      ERM; Ezrin/radixin/moesin family

    5. XM_025155421.3 → XP_025011189.1  merlin isoform X4

      UniProtKB/TrEMBL
      Q6RW63
      Conserved Domains (4) summary
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 584
      ERM; Ezrin/radixin/moesin family
      cl27293
      Location:307 → 369
      UFD1; Ubiquitin fusion degradation protein UFD1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      11076462..11117700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046928017.1 → XP_046783973.1  merlin isoform X1

      UniProtKB/TrEMBL
      A0A8V0WZJ7, Q6RW63

    2. XM_046928020.1 → XP_046783976.1  merlin isoform X3

      UniProtKB/TrEMBL
      Q6RW63

    3. XM_046928018.1 → XP_046783974.1  merlin isoform X2

      UniProtKB/TrEMBL
      Q6RW63

    4. XM_046928019.1 → XP_046783975.1  merlin isoform X2

      UniProtKB/TrEMBL
      Q6RW63

    5. XM_046928021.1 → XP_046783977.1  merlin isoform X4

      UniProtKB/TrEMBL
      Q6RW63
    Nucleotide Protein Strain
    Heading Accession and Version

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